(3-(Hydroxymethyl)-4-(trifluoromethoxy)phenyl)boronic acid CAS 1451393-59-1
| CAS No. | 1451393-59-1 |
| Molecular Formula | C8H8BF3O4 |
| Molecular Weight | 235.95 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
(3-(Hydroxymethyl)-4-(trifluoromethoxy)phenyl)boronic acid (CAS 1451393-59-1) is a high-purity analytical reference standard with the molecular formula C8H8BF3O4 and a molecular weight of 235.95 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, (3-(Hydroxymethyl)-4-(trifluoromethoxy)phenyl)boronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 235.95 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8BF3O4 |
| Molecular Weight | 235.95 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Hydroxymethyl Standards
- 2-(Hydroxymethyl)-5-(trifluoromethoxy)phenylboronic acid (CAS 2121514-23-4)
- 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate (CAS 1022927-90-7)
- 2-(4-(Hydroxymethyl)piperidin-1-yl)nicotinic acid (CAS 1094389-65-7)
- 3-(3-(Hydroxymethyl)piperidine-1-carbonyl)pyridin-2(1H)-one (CAS 1156234-76-2)
- 6-(3-(Hydroxymethyl)piperidin-1-yl)nicotinic acid (CAS 1156249-64-7)
- (3-(Hydroxymethyl)pyrrolidin-1-yl)(2-methoxypyridin-3-yl)methanone (CAS 1283957-26-5)
- 2-(2-(Hydroxymethyl)piperidin-1-yl)nicotinic acid (CAS 1284772-87-7)
- 2-(hydroxymethyl)-2,5,7,8-tetramethylchroman-6-ol (CAS 79907-49-6)
Recommended Standards
- 4-Methoxy-2-(trifluoromethoxy)phenylboronic acid (CAS 1391918-92-5)
- (2-Methoxy-5-(trifluoromethoxy)phenyl)boronic acid (CAS 290832-43-8)
- (3-Methoxy-5-(trifluoromethoxy)phenyl)boronic acid (CAS 1256345-88-6)
- (2-Methoxy-6-(trifluoromethoxy)phenyl)boronic acid (CAS 309977-92-2)
- 2,4-Bis(4-methylpiperazin-1-yl)aniline (CAS 797813-15-1)
- 1-Cycloheptyl-4,5-diphenyl-1H-imidazole (CAS 133657-06-4)
- 1-Benzyl-6-hydroxy-4,4-dimethylpiperidin-2-one (CAS 1253226-26-4)
- tert-Butyl 7-[(dimethylamino)sulfonyl]-4a-hydroxyoctahydro-2,7-naphthyridine-2(1H)-carboxylate (CAS 2096985-61-2)
- 4-[(3-methoxycyclohexyl)oxy]pyrimidin-2-amine (CAS 1517647-28-7)
- N-Methylpiperidine-1-carboxamide (CAS 36879-48-8)
- 2,4,5-Trichloro-N-[4-(tetrahydro-2-furanylmethoxy)benzyl]aniline (CAS 1040681-29-5)
- (2-Ethylfuran-3-yl)(phenyl)methanol (CAS 1343319-75-4)
- 2-Chloro-4-fluoro-6-methylbenzothiazole (CAS 1188044-02-1)
- 1-His-N-a-ethylidene Semaglutide (CAS CATO-C4X-2226252)
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