5-Methyl-N-(2-(trifluoromethyl)phenyl)isoxazole-3-carboxamide CAS 145440-85-3
| CAS No. | 145440-85-3 |
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Methyl-N-(2-(trifluoromethyl)phenyl)isoxazole-3-carboxamide.
5-Methyl-N-(2-(trifluoromethyl)phenyl)isoxazole-3-carboxamide (CAS 145440-85-3) is a high-purity analytical reference standard with the molecular formula C12H9F3N2O2 and a molecular weight of 270.21 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 5-Methyl-N-(2-(trifluoromethyl)phenyl)isoxazole-3-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 270.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9F3N2O2 |
| Molecular Weight | 270.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- Ethyl 2-cyano-3-[(2,3,4-trifluorophenyl)amino]prop-2-enoate (CAS 144367-60-2)
- 2,2,2-trifluoroethyl N-(quinolin-3-yl)carbamate (CAS 1455104-41-2)
- 1-(2-(Trifluoromethyl)benzyl)-1h-imidazole-2-carboxylic acid (CAS 1439903-16-8)
- 1-{[4-(trifluoromethoxy)phenyl]methyl}-1H-pyrazole-4-carbaldehyde (CAS 1481183-82-7)
- tert-Butyl (4-amino-1,1,1-trifluoro-4-oxobutan-2-yl)carbamate (CAS 1355083-49-6)
- Methyl 2-amino-2-methylpent-4-enoate (CAS 120963-07-7)
- Curculigoside B (CAS 143601-09-6)
- 2-(6-Bromo-5-(difluoromethyl)-4-(trifluoromethyl)pyridin-3-yl)acetic acid (CAS 1807008-01-0)
- tert-Butyl 3-[(2-methylcyclohexyl)amino]propanoate (CAS 1221342-43-3)
- 5-(Chloromethyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)pyridine (CAS 906352-80-5)
- N-(2-Bromophenyl)-1-butyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide (CAS 303093-27-8)
- 3-((Cyanomethyl)sulfonyl)-5-methylisothiazole-4-carbonitrile (CAS 339021-05-5)
- 1,2-Diphenyl-1,2-di(piperidin-1-yl)ethane (CAS 35278-85-4)
- Semaglutide Impurity 123 (CAS 71997-93-8)
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