2-(4-(1,1-Difluoroethyl)phenyl)thiophene CAS 1458041-73-0
| CAS No. | 1458041-73-0 |
| Molecular Formula | C12H10F2S |
| Molecular Weight | 224.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(4-(1,1-Difluoroethyl)phenyl)thiophene (CAS 1458041-73-0), molecular formula C12H10F2S and molecular weight 224.27 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to sulfur-containing functionality, fluorine substitution, an aromatic ring system, 2-(4-(1,1-Difluoroethyl)phenyl)thiophene is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 224.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H10F2S |
| Molecular Weight | 224.27 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Difluoroethyl Standards
- n-(2,2-Difluoroethyl)-2-(trifluoromethyl)aniline (CAS 1179732-72-9)
- 1-(2,2-Difluoroethyl)-1h-indole-6-carboxylic acid (CAS 1340503-49-2)
- 1-[4-(1,1-Difluoroethyl)-phenyl]piperazine (CAS 1186195-00-5)
- 3-(4-(2,2-Difluoroethyl)piperazin-1-yl)propanoic acid (CAS 1182922-40-2)
- 2-(2,2-Difluoroethyl)-3,4-dimethyl-2h-pyrazolo[3,4-b]pyridin-6-ol (CAS 1018163-56-8)
- Methyl 2-(1-(2,2-difluoroethyl)piperidin-4-yl)acetate (CAS 1245772-02-4)
- 2-(4-(1,1-Difluoroethyl)piperidin-1-yl)propanoic acid (CAS 1949815-71-7)
- Ethyl 1-(2,2-difluoroethyl)piperidine-3-carboxylate (CAS 937603-28-6)
Recommended Standards
- 4-Fluoro-3-(hexyloxy)benzaldehyde (CAS 1443349-74-3)
- rel-3-((2S,6R)-2,6-dimethylmorpholino)-5-fluoroaniline (CAS 1603409-00-2)
- 1-(3-Fluoro-5-(isopentyloxy)phenyl)ethanone (CAS 1443349-20-9)
- N,N-dibutyl-2,2,2-trifluoroacetimidamide (CAS 1650-14-2)
- 3-(3-methyltetrahydrofuran-3-yl)prop-2-ynoic acid (CAS 2164853-19-2)
- 3,5-Dihexanamido-2,4,6-triiodo-benzoic Acid (CAS 67032-31-9)
- Ethyl 4-hydroxy-2-(trifluoromethoxy)benzoate (CAS 1261477-66-0)
- Bromazepam EP Impurity C (CAS 868350-97-4)
- Pimaricin (CAS 7681-93-8)
- 5-Fluoro-2-(3-methoxyphenoxy)phenylamine (CAS 937596-43-5)
- (1R)-1-[(2R,3R,4R)-3-(benzoyloxy)-4-hydroxy-5-methoxy-4-methyloxolan-2-yl]ethyl benzoate (CAS 1417563-67-7)
- 5-methylspiro[indoline-3,4-piperidine]-2-one;hydrochloride (CAS 2306270-99-3)
- 1-(4-Methoxyphenyl)cyclopropanecarbaldehyde (CAS 34603-55-9)
- Tirzepatide Impurity 37 (CAS CATO-C4X-324037)
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