Tiagabine Related Compound A (F0E177) CAS 145821-60-9
| CAS No. | 145821-60-9 |
| Molecular Formula | C22H29NO2S2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tiagabine Related Compound A (F0E177) is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Tiagabine Related Compound A (F0E177) (CAS 145821-60-9) is a high-purity analytical reference standard with the molecular formula C22H29NO2S2HCl and a molecular weight of 440.06 g/mol.
The molecular framework of Tiagabine Related Compound A (F0E177) (C22H29NO2S2HCl) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29NO2S2 HCl |
| Molecular Weight | 440.06 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Tiagabine Standards
- Tiagabine Isomer (25 mg) (1-(4,4-Bis(4-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid) (CAS 109857-65-0)
- Tiagabine D5. HCl (CAS 109857-73-0)
- Tiagabine Impurity 5 (Stage I Impurity) (CAS 109857-81-0)
- Tiagabine (free base) (CAS 115103-54-3)
- Tiagabine-methyl-d6 Hydrochloride (CAS 1217808-68-8)
- Tiagabine Hydrochloride Monohydrate (CAS 145821-57-4)
- Tiagabine Hydrochloride (CAS 145821-59-6)
- Tiagabine alcohol analog (CAS 847233-27-6)
Recommended Standards
- 1-(2-(Trifluoromethyl)phenyl)-1H-pyrrole-2-carbaldehyde (CAS 312303-90-5)
- 6-Bromooxazolo[5,4-b]pyridine (CAS 886372-90-3)
- 1-(2-Hydroxyphenyl)-2-phenylpropan-1-one (CAS 42772-82-7)
- 2-Bromo-1-(2,4-dimethyl-5-thiazolyl)ethanone (CAS 7520-91-4)
- 1-(3,4-Dichlorophenyl)-2-(pyrazin-2-yl)ethanone (CAS 88283-35-6)
- 7-Chloro-3-oxo-2h,3h,4h-pyrido[3,2-b][1,4]oxazine-6-carboxylic acid (CAS 877177-24-7)
- 898767-43-6 4-(3-Bromo-5-methylphenyl)-4-oxobutanoic acid DTXSID90645388 (CAS 898767-43-6)
- ω-Conotoxin MVIIC TFA salt (CAS 147794-23-8)
- 1,3-Dioxaspiro[4.5]decan-4-one (CAS 27032-96-8)
- C-Peptide (Proinsulin) (CAS 59112-80-0)
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