Pranoprofen Impurity 5 CAS 145986-74-9
| CAS No. | 145986-74-9 |
| Molecular Formula | C16H15NO3 |
| Molecular Weight | 269.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Pranoprofen Impurity 5 (CAS 145986-74-9) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15NO3 and a molecular weight of 269.30 g/mol.
The molecular framework of Pranoprofen Impurity 5 (C16H15NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H15NO3 |
| Molecular Weight | 269.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 1 |
Related Pranoprofen Standards
- Pranoprofen Impurity 12 (CAS CATO-C4X-181112)
- Pranoprofen Impurity 9 (CAS CATO-C4X-18119)
- Pranoprofen Impurity 2 (CAS 52549-19-6)
- Pranoprofen Impurity 66 (CAS CATO-C4X-181166)
- Pranoprofen Impurity 7 (CAS CATO-C4X-18117)
- Pranoprofen Impurity 14 (CAS CATO-C4X-181114)
- Pranoprofen Impurity 15 (CAS CATO-C4X-181115)
- Pranoprofen Impurity 21 (CAS CATO-C4X-181121)
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