Thiopropazate Dihydrochloride CAS 146-28-1
| CAS No. | 146-28-1 |
| Molecular Formula | C23H28ClN3O2S |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Thiopropazate Dihydrochloride (CAS 146-28-1), molecular formula C23H28ClN3O2SHCl and molecular weight 482.46 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Thiopropazate Dihydrochloride is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 482.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H28ClN3O2S 2*HCl |
| Molecular Weight | 482.46 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Thiopropazate Standards
Recommended Standards
- Methyl 3,5-dichloro-2-{[(dimethylamino)sulfonyl]oxy}benzenecarboxylate (CAS 338405-94-0)
- Ethyl 2-(((benzyloxy)carbonyl)imino)-3,3,3-trifluoropropanoate (CAS 126535-92-0)
- n-{[(2-bromophenyl)carbamoyl]methyl}-2-chloroacetamide (CAS 929973-30-8)
- Spiramycin I (CAS CATO-C4X-2325)
- Itraconazole Impurity 64 (CAS 2570971-58-1)
- 2-Methyl-4-(3-phenylpropoxy)aniline (CAS 946742-66-1)
- 2-(4-Bromo-3,5-dimethyl-1h-pyrazol-1-yl)-N-methylacetamide (CAS 1205135-49-4)
- 5-Bromo-2-[2-(methylanilino)ethoxy]aniline (CAS 946664-93-3)
- Adapalene impurity 20 (CAS CATO-C4X-180920)
- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
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