5-Chloro-2-cyclopropyl-1H-imidazo[4,5-b]pyridine CAS 146014-81-5
| CAS No. | 146014-81-5 |
| Molecular Formula | C9H8ClN3 |
| Molecular Weight | 193.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-2-cyclopropyl-1H-imidazo[4,5-b]pyridine.
CATO supplies 5-Chloro-2-cyclopropyl-1H-imidazo[4,5-b]pyridine (CAS 146014-81-5), a certified reference material (molecular formula C9H8ClN3, MW 193.63 g/mol) for analytical method development and quality control.
5-Chloro-2-cyclopropyl-1H-imidazo[4,5-b]pyridine (C9H8ClN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-2-cyclopropyl-1H-imidazo[4,5-b]pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8ClN3 |
| Molecular Weight | 193.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-(4-Chloro-1h-pyrazol-1-yl)aniline (CAS 1006467-19-1)
- 4-Benzyl-3-chloro-4H-1,2,4-triazole (CAS 1019031-93-6)
- 3-chloro-5-methyl-4-phenyl-4H-1,2,4-triazole (CAS 1019032-00-8)
- methyl 2-(3-chloro-N-methylpropanamido)acetate (CAS 1020992-22-6)
- 2-Chloro-1-(1h-indol-5-yl)ethan-1-one (CAS 103028-56-4)
- 7-Chloro-2-cyclopropyl-3H-imidazo[4,5-b]pyridine (CAS 1046822-79-0)
- 4-Chloro-3-methyl-5-phenylisoxazole (CAS 10557-76-3)
- 6-Chloro-8-(prop-1-en-2-yl)imidazo[1,2-b]pyridazine (CAS 105949-21-1)
Recommended Standards
- (3-Chloroisoquinolin-4-yl)methanol (CAS 1446346-71-9)
- 2-(5-chloro-2,3-dihydro-1-benzofuran-7-yl)acetonitrile (CAS 1461707-00-5)
- 8-Chloro-2,3-dimethylpyrido[2,3-b]pyrazine (CAS 1443289-01-7)
- 1-(2-Chlorophenyl)-1h-pyrazol-5-amine (CAS 14678-96-7)
- 4-(4-Fluorophenyl)-2,5-dimethylthiazole (CAS 675856-63-0)
- (8AR)-8a-Methyl-3,4,8,8a-tetrahydronaphthalene-1,6(2H,7H)-dione (CAS 100348-93-4)
- 4-Amino-3-bromo-5-(difluoromethyl)picolinonitrile (CAS 1805053-53-5)
- 2,6-Dimethyl-4-(trifluoromethyl)aniline (CAS 144991-53-7)
- 4-([1,1'-Biphenyl]-4-yl)pyrimidine (CAS 92867-89-5)
- 2-(3-Amino-5-pyrazolyl)acetic Acid (CAS 174891-10-2)
- (3-Methoxy-5-(thiazol-5-yl)phenyl)boronic acid (CAS 2225155-36-0)
- 2-(2-Bromophenyl)-4,6-diphenyl-1,3,5-triazine (CAS 77989-15-2)
- 2,3-Difluoro-6-methylbenzoyl chloride (CAS 1806370-17-1)
- Tirzepatide Impurity 51 (CAS CATO-C4X-324051)
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