N-(2,5-Dimethylphenyl)-2,2,2-trifluoroacetamide CAS 14618-48-5

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(2,5-Dimethylphenyl)-2,2,2-trifluoroacetamide.

N-(2,5-Dimethylphenyl)-2,2,2-trifluoroacetamide (CAS 14618-48-5) is a high-purity analytical reference standard with the molecular formula C10H10F3NO and a molecular weight of 217.19 g/mol.

The molecular framework of N-(2,5-Dimethylphenyl)-2,2,2-trifluoroacetamide (C10H10F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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