(1R,6R,8R,9R,14R,16R)-8-(2-Amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-2,4,7,10,12,15-hexaoxa-3λ,11λ-diphosphatricyclo[12.2.1.1,]octadecane-3,11-dione CAS 1465774-27-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1R,6R,8R,9R,14R,16R)-8-(2-Amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-2,4,7,10,12,15-hexaoxa-3λ,11λ-diphosphatricyclo[12.2.1.1,]octadecane-3,11-dione.

(1R,6R,8R,9R,14R,16R)-8-(2-Amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-2,4,7,10,12,15-hexaoxa-3λ,11λ-diphosphatricyclo[12.2.1.1,]octadecane-3,11-dione (CAS 1465774-27-9), molecular formula C20H28N10O13P2Na and molecular weight 701.44 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (1R,6R,8R,9R,14R,16R)-8-(2-Amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-2,4,7,10,12,15-hexaoxa-3λ,11λ-diphosphatricyclo[12.2.1.1,]octadecane-3,11-dione (C20H28N10O13P2Na) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), (1R,6R,8R,9R,14R,16R)-8-(2-Amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-2,4,7,10,12,15-hexaoxa-3λ,11λ-diphosphatricyclo[12.2.1.1,]octadecane-3,11-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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