Docetaxel Impurity 51 CAS 147058-27-3
| CAS No. | 147058-27-3 |
| Molecular Formula | C18H21NO3 |
| Molecular Weight | 299.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Docetaxel Impurity 51 (C18H21NO3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Docetaxel Impurity 51 (CAS 147058-27-3) is a certified pharmaceutical impurity reference standard with the molecular formula C18H21NO3 and a molecular weight of 299.36 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Docetaxel Impurity 51 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H21NO3 |
| Molecular Weight | 299.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
Related Docetaxel Standards
- Docetaxel Impurity 89 (CAS CATO-C4X-161989)
- Docetaxel Impurity 90 (CAS CATO-C4X-161990)
- Docetaxel Impurity 16 (CAS 161759-90-6)
- Docetaxel Impurity 66 (CAS 158830-39-8)
- Docetaxel Impurity 67 (CAS 124605-42-1)
- Docetaxel Impurity 72 (CAS 959123-35-4)
- Docetaxel Impurity 22 (CAS 161183-22-8)
- Docetaxel Impurity 52 (CAS 154428-10-1)
Recommended Standards
- Pioglitazone impurity 35 (CAS CATO-C4X-138335)
- Dopamine Impurity 37 (CAS CATO-C4X-190837)
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- Dopamine Impurity 41 (CAS CATO-C4X-190841)
- Norepinephrine Impurity 106 (CAS CATO-C4X-1514106)
- Relebactam Impurity 91 (CAS 2649587-23-3)
- Apixaban Impurity 42 (CAS 1704504-93-7)
- 2-(4-Amino-1h-pyrazol-1-yl)propanoic acid (CAS 1006455-81-7)
- 3-(Cyclooctylsulfamoyl)benzene-1-carbothioamide (CAS 1036619-17-6)
- 5-(2,5-Dimethylphenoxy)pentanoic acid (CAS 443924-74-1)
- 2H-Thiopyran-4-carbonitrile, 4-(4-bromophenyl)tetrahydro- (CAS 2845280-64-8)
- 1-Ethynyl-2-nitro-4-(trifluoromethyl)benzene (CAS 1260743-50-7)
- Benzyl (S)-(1-((methoxymethyl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (CAS 114744-84-2)
- D-Ile12-Tirzepatide (CAS CATO-CPTD788921)
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