6-(2-Chloroacetyl)-7-fluoro-1,2,3,4-tetrahydroquinolin-2-one CAS 148136-15-6
| CAS No. | 148136-15-6 |
| Molecular Formula | C11H9ClFNO2 |
| Molecular Weight | 241.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-(2-Chloroacetyl)-7-fluoro-1,2,3,4-tetrahydroquinolin-2-one.
6-(2-Chloroacetyl)-7-fluoro-1,2,3,4-tetrahydroquinolin-2-one (CAS 148136-15-6) is a high-purity analytical reference standard with the molecular formula C11H9ClFNO2 and a molecular weight of 241.65 g/mol.
6-(2-Chloroacetyl)-7-fluoro-1,2,3,4-tetrahydroquinolin-2-one (C11H9ClFNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 6-(2-Chloroacetyl)-7-fluoro-1,2,3,4-tetrahydroquinolin-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H9ClFNO2 |
| Molecular Weight | 241.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloroacetyl Standards
- (2-Chloroacetyl)-D-phenylalanine (CAS 137503-97-0)
- (2-Chloroacetyl)-L-phenylalanine (CAS 721-65-3)
- 2-[(2-Chloroacetyl)amino]-3-methylbenzoic Acid Methyl Ester (CAS 77093-79-9)
- Methyl 3-{[(chloroacetyl)amino]methyl}benzoate (CAS 74553-27-8)
- N-Chloroacetyl-DL-phenylalanine (CAS 7765-11-9)
- 6-(2-Chloroacetyl)-2H-benzo[b][1,4]thiazin-3(4H)-one (CAS 145736-61-4)
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- 1-(chloroacetyl)-4-(methylsulfonyl)piperazine (CAS 875164-36-6)
Recommended Standards
- 4-(Chloromethyl)-1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazole (CAS 1250819-39-6)
- Ethyl 4-chloro-5-fluoro-1H-indole-2-carboxylate (CAS 153500-78-8)
- 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarbonyl chloride (CAS 1219937-98-0)
- Ethyl 6-chloro-5-fluoro-1H-indole-2-carboxylate (CAS 169674-00-4)
- (1,1-Dioxidotetrahydrothiophen-3-yl)tyrosine (CAS 415919-39-0)
- 3-(2-Fluoro-6-iodophenyl)-1,2,4-oxadiazole (CAS 1262412-81-6)
- 3-Isopropoxy-1-methyl-1H-indazole-6-carbaldehyde (CAS 1923064-94-1)
- 2-Phenyl-5-(propan-2-yl)-1,3-oxazole-4-carboxylic acid (CAS 939376-87-1)
- 3-Amino-2-fluoro-3'-(trifluoromethoxy)biphenyl (CAS 1261780-30-6)
- 4-Amino-5-fluoro-2-hydroxybenzonitrile (CAS 129911-04-2)
- Ethyl 3-bromo-5-(trifluoromethoxy)-1H-indole-2-carboxylate (CAS 1227955-21-6)
- 3-Cyclopropylisonicotinic acid (CAS 1256785-01-9)
- Ethyl 2-phenylacetoacetate (CAS 5413-05-8)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
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