1-(4-Chloro-2-fluoro-5-methoxyphenyl)ethanone CAS 148254-31-3

Purity 97%+In StockPharmaceutical Standards
CAS No.148254-31-3
Molecular FormulaC9H8ClFO2
Molecular Weight202.61 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-(4-Chloro-2-fluoro-5-methoxyphenyl)ethanone CAS 148254-31-3 chemical structure

Description

The occurrence of 1-(4-Chloro-2-fluoro-5-methoxyphenyl)ethanone is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

1-(4-Chloro-2-fluoro-5-methoxyphenyl)ethanone (CAS 148254-31-3), molecular formula C9H8ClFO2 and molecular weight 202.61 g/mol, is a CATO reference standard with documented purity and traceability.

1-(4-Chloro-2-fluoro-5-methoxyphenyl)ethanone (C9H8ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-(4-Chloro-2-fluoro-5-methoxyphenyl)ethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC9H8ClFO2
Molecular Weight202.61 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at room temperature, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1999
Halogen ContentF/Cl-containing

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