6-(Chloromethyl)nicotinic acid CAS 148258-27-9
| CAS No. | 148258-27-9 |
| Molecular Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C7H6ClNO2, 6-(Chloromethyl)nicotinic acid contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 171.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
6-(Chloromethyl)nicotinic acid (CAS 148258-27-9) is a high-purity analytical reference standard with the molecular formula C7H6ClNO2 and a molecular weight of 171.58 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(Chloromethyl)nicotinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 7-(Chloromethyl)-[1,3]dioxolo[4,5-b]pyridine (CAS 1260663-88-4)
- 2-(Chloromethyl)-4-hydroxynicotinaldehyde (CAS 1393543-56-0)
- 5-(Chloromethyl)-4-hydroxynicotinaldehyde (CAS 1393545-23-7)
- 4-(Chloromethyl)-6-hydroxypicolinaldehyde (CAS 1393551-36-4)
- 6-(Chloromethyl)-3-hydroxypicolinaldehyde (CAS 1393575-63-7)
- 5-(Chloromethyl)picolinic acid (CAS 53234-53-0)
- 2-(Chloromethyl)-6-methoxy-4-methylpyridine (CAS 100636-47-3)
- 2-(Chloromethyl)-3-(methoxymethyl)pyridine (CAS 100716-57-2)
Recommended Standards
- 5-Chloropicolinohydrazide (CAS 145835-01-4)
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- 4-Chloro-N-hydroxybenzamide (CAS 1613-88-3)
- tert-Butyl((3-(hydroxymethyl)azetidin-3-yl)methyl)carbamatehydrochloride (CAS 2173991-96-1)
- 7-Bromo-4-ethyl-1H-indole (CAS 161988-90-5)
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- Ethyl 1-(3-bromophenyl)-5-cyclopropyl-1H-pyrazole-4-carboxylate (CAS 1491754-63-2)
- 1H-Isoxazolo[5,4-g]indazole (CAS 173894-82-1)
- [Pd(allyl)Cl]<SUB>2</SUB> (CAS 12012-95-2)
- tert-Butyl 2-(chlorosulfonyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate (CAS 2878499-88-6)
- Ethyl 2-((4-nitrophenoxy)carbonyloxy)acetate (CAS 236418-39-6)
- 2-Benzyl 6-tert-butyl 2,6-diazaspiro[3.3]heptane-2,6-dicarboxylate (CAS 1542158-69-9)
- Cholecystokinin Octapeptide (1-4) (desulfated) (CAS 80790-40-5)
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