4-(Trifluoromethyl)isophthalonitrile CAS 1483-43-8
| CAS No. | 1483-43-8 |
| Molecular Formula | C9H3F3N2 |
| Molecular Weight | 196.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Trifluoromethyl)isophthalonitrile (CAS 1483-43-8) is a high-purity analytical reference standard with the molecular formula C9H3F3N2 and a molecular weight of 196.13 g/mol.
4-(Trifluoromethyl)isophthalonitrile (C9H3F3N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H3F3N2 |
| Molecular Weight | 196.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 1-(2-Hydroxyethyl)-3-(trifluoromethyl)-1H-pyrazol-5-ol (CAS 143706-80-3)
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- 2-(Difluoromethyl)-5-iodo-3-(trifluoromethyl)pyridine-6-acetic acid (CAS 1805431-18-8)
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- 11-Fluorosulfonylperfluoro(2,5,8-trimethyl-3,6,9-trioxaundecanoyl) fluoride (CAS 4628-44-8)
- Ethyl 4-bromo-5,8-difluoroquinoline-3-carboxylate (CAS 1242260-20-3)
- 6-Hydroxythiochroman-4-one 1,1-dioxide (CAS 1374667-26-1)
- Methyl 4-methyl-3-propionylbenzoate (CAS 1799749-63-5)
- 3-(1,3-Dioxoisoindolin-2-yl)-4-methylbenzoic acid (CAS 420101-13-9)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
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