1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyrrolidine-2-carboxylic acid dihydrochloride CAS 1485747-67-8
| CAS No. | 1485747-67-8 |
| Molecular Formula | C12H19F3N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyrrolidine-2-carboxylic acid dihydrochloride (C12H19F3N2O2HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyrrolidine-2-carboxylic acid dihydrochloride (CAS 1485747-67-8) is a high-purity analytical reference standard with the molecular formula C12H19F3N2O2HCl and a molecular weight of 316.75 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]pyrrolidine-2-carboxylic acid dihydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H19F3N2O2 2*HCl |
| Molecular Weight | 316.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related trifluoroethyl Standards
- 2,2,2-trifluoroethyl 4-cyanophenylcarbamate (CAS 1000932-40-0)
- 5-(2,2,2-Trifluoroethyl)-1H-pyrazol-3-amine (CAS 1001354-48-8)
- 1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid (CAS 1006340-71-1)
- 3-Methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-amine (CAS 1006448-59-4)
- Methyl 1-(2,2,2-trifluoroethyl)-1h-pyrazole-4-carboxylate (CAS 1006461-60-4)
- 3-Methyl-1-(2,2,2-trifluoroethyl)-1h-pyrazole-4-carbaldehyde (CAS 1006471-12-0)
- Ethyl 1-(2,2,2-trifluoroethyl)-1H-pyrazole-5-carboxylate (CAS 1006486-11-8)
- 5-Methyl-1-(2,2,2-trifluoroethyl)-1h-pyrazole-3-carboxylic acid (CAS 1006486-45-8)
Recommended Standards
- 6-(2,2-Diethoxyethoxy)-2-(methylthio)pyrimidin-4-amine (CAS 928468-02-4)
- 2-(3-Nitrophenyl)-4-phenylthiazole (CAS 1387473-42-8)
- 2,5-Bis(2-fluorophenyl)-1,3,4-oxadiazole (CAS 62681-98-5)
- Ertapenem Impurity 50 (CAS CATO-C4X-163350)
- Tert-butyl 7,7-difluoro-2,9-diazaspiro[5.5]Undecane-2-carboxylate (CAS 1784088-76-1)
- 2-Bromo-4-(3,4-dichlorophenyl)thiazole (CAS 412923-60-5)
- (4S,5R)-4,5-Dihydroxypiperidin-2-one (CAS 1429476-35-6)
- 3-(4-Isopropylbenzyl)-6-(thiophen-2-yl)isoxazolo[5,4-b]pyridine-4-carboxylic acid (CAS 1263210-60-1)
- Ethyl 5-(2-bromobenzyl)-1,2,4-oxadiazole-3-carboxylate (CAS 1216696-40-0)
- Semaglutide impurity 33 (CAS CATO-C4X-222633)
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