Asciminib Impurity 2 CAS 1492954-67-2
| CAS No. | 1492954-67-2 |
| Molecular Formula | C25H26ClF2N5O4 |
| Molecular Weight | 533.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 533.95 g/mol gives Asciminib Impurity 2 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Asciminib Impurity 2 (CAS 1492954-67-2, C25H26ClF2N5O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C25H26ClF2N5O4, Asciminib Impurity 2 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 533.95 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Asciminib Impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H26ClF2N5O4 |
| Molecular Weight | 533.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Asciminib Standards
Recommended Standards
- N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-((4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 477330-00-0)
- 1,3,6,8-Tetrabromopyrene (CAS 128-63-2)
- 1,3-Bis(5-(trimethylstannyl)thiophen-2-yl)propane (CAS 1679325-61-1)
- Lenvatinib Impurity 181 (CAS CATO-C4X-1140181)
- Pomalidomide Impurity 30 (CAS CATO-C4X-135430)
- Trifarotene impurity 21 (CAS CATO-C4X-313221)
- Ramelteon Impurity 29 (CAS CATO-C4X-262229)
- 5-Bromo-3-(trifluoromethyl)-7H-pyrrolo[2,3-c]pyridazine (CAS 2091468-90-3)
- 3-(2,5-Difluorophenyl)-1-methyl-1h-pyrazole-5-carboxylic acid (CAS 1245171-63-4)
- 2-Amino-1-(2,4-difluorophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1094279-38-5)
- 5-Bromo-1-isobutyl-1H-indole-2-carboxylic acid (CAS 2204053-33-6)
- 2,3-Dibromo-2-butene-1,4-diol (CAS 3234-02-4)
- 2-(4-Methoxybenzyl)-2H-spiro[benzo[d]isothiazole-3,3'-pyrrolidine] 1,1-dioxide (CAS 1422068-56-1)
- D-Phe6-Tirzepatide (CAS CATO-CPTD788925)
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