Acetazolamide EP Impurity D CAS 14949-00-9
| CAS No. | 14949-00-9 |
| Molecular Formula | C2H4N4O2S2 |
| Molecular Weight | 180.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Acetazolamide EP Impurity D (CAS 14949-00-9), a pharmacopoeial impurity reference standard (molecular formula C2H4N4O2S2, MW 180.21 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Acetazolamide EP Impurity D (C2H4N4O2S2) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C2H4N4O2S2 |
| Molecular Weight | 180.21 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Acetazolamide Standards
- Acetazolamide Impurity 8 (CAS 4454-63-1)
- Acetazolamide EP Impurity A (CAS 60320-32-3)
- Acetazolamide EP Impurity C (CAS 32873-56-6)
- Acetazolamide Impurity 7 (CAS 50608-12-3)
- Acetazolamide EP Impurity B (CAS 5393-55-5)
- Acetazolamide (CAS 59-66-5)
- Acetazolamide EP Impurity E (CAS 827026-60-8)
- Acetazolamide-d3 (CAS 1189904-01-5)
Recommended Standards
- 1-(5-Hydroxy-2-pyrimidinyl)piperazine 55745-85-2 C8H12N4O W6968 (CAS 55745-85-2)
- Phenazine (CAS 92-82-0)
- trans-1-Ethyl-4-trifluoromethyl-cyclohexane (CAS 891782-76-6)
- 1,10-Phenanthroline (CAS 66-71-7)
- Desloratadine Impurity 17 (CAS 169253-26-3)
- Atropine Impurity 22 (CAS 16052-33-8)
- Minoxidil Impurity 63 (CAS CATO-C4X-170063)
- 2-(2-Ethyl-1h-imidazol-1-yl)benzoic acid (CAS 159589-72-7)
- 4-Benzylpiperidine-1-carboxamide (CAS 31252-58-1)
- 4-(Difluoromethyl)-2,6-diiodo-3-methoxypyridine (CAS 1806824-71-4)
- 3-Fluoro-5-(isopentyloxy)benzaldehyde (CAS 1443336-49-9)
- 2-amino-2-{4-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl}acetic acid (CAS 1779644-89-1)
- 3-Isobutyramidophenyl tert-butylcarbamate (CAS 17787-98-3)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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