4-(4-(Trifluoromethyl)piperidine-1-carbonyl)benzoic acid CAS 1495436-20-8
| CAS No. | 1495436-20-8 |
| Molecular Formula | C14H14F3NO3 |
| Molecular Weight | 301.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-(Trifluoromethyl)piperidine-1-carbonyl)benzoic acid.
CATO supplies 4-(4-(Trifluoromethyl)piperidine-1-carbonyl)benzoic acid (CAS 1495436-20-8), a certified reference material (molecular formula C14H14F3NO3, MW 301.26 g/mol) for analytical method development and quality control.
4-(4-(Trifluoromethyl)piperidine-1-carbonyl)benzoic acid (C14H14F3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-(4-(Trifluoromethyl)piperidine-1-carbonyl)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H14F3NO3 |
| Molecular Weight | 301.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- Phenyl(2-(trifluoromethyl)quinolin-3-yl)methanone (CAS 1380602-46-9)
- 1-[4-(trifluoromethyl)benzoyl]piperidine-4-carboxylic acid (CAS 856215-36-6)
- 2-((2-Methyl-7-(trifluoromethyl)quinolin-4-yl)thio)acetic acid (CAS 1208785-74-3)
- Ethyl 2-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate (CAS 132089-39-5)
- Methyl 2-((2-(trifluoromethyl)quinolin-4-yl)thio)acetate (CAS 175203-42-6)
- 2-(4-Trifluoromethyl-phenyl)-thiazole-4-carboxylic acid ethyl ester (CAS 175204-88-3)
- 2-(5-Methyl-2-(3-(trifluoromethyl)phenyl)thiazol-4-yl)acetic acid (CAS 924868-87-1)
- 2-(5-Methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)acetic acid (CAS 924868-88-2)
Recommended Standards
- 2-(2-Methyl-1-trifluoromethoxymethyl-propyl)-isoindole-1,3-dione (CAS 1408279-75-3)
- 4-(3-Trifluoromethylbenzoyl)quinoline (CAS 1706429-71-1)
- 4-(4-Trifluoromethylbenzoyl)quinoline (CAS 1706443-60-8)
- Ethyl 3-amino-1,6-dimethyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylate (CAS 1353877-98-1)
- (2-Methoxyphenyl)(triphenylphosphine)gold (CAS 1243985-65-0)
- (3-Aminophenyl)(4-chlorophenyl)methanone (CAS 62261-26-1)
- 4-(Pyridin-3-yl)-1H-imidazol-5-amine (CAS 851363-77-4)
- 1-(Prop-2-yn-1-yl)-1H-benzo[d][1,2,3]triazole (CAS 142321-23-1)
- (3E)-1,1,1-Trifluoro-4-{[4-(trifluoromethoxy)phenyl]amino}but-3-en-2-one (CAS 1164457-71-9)
- Levomedetomidine Hydrochloride (CAS 190000-46-5)
- 1-((2R,3R,5R)-5-(Aminomethyl)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS 286939-22-8)
- 3-Chloro-4-(trifluoromethyl)pyridin-2-ol (CAS 1227602-53-0)
- 4-(2-Fluorophenoxy)-2-(trifluoromethyl)aniline (CAS 946784-47-0)
- Calcineurin Autoinhibitory Peptide (CAS 148067-21-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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