2-Butyl-4-chloro-1H-imidazole-5-carboxylic acid CAS 149968-28-5
| CAS No. | 149968-28-5 |
| Molecular Formula | C8H11ClN2O2 |
| Molecular Weight | 202.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Butyl-4-chloro-1H-imidazole-5-carboxylic acid.
As a process- or degradation-related impurity, 2-Butyl-4-chloro-1H-imidazole-5-carboxylic acid (CAS 149968-28-5, C8H11ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of 2-Butyl-4-chloro-1H-imidazole-5-carboxylic acid (C8H11ClN2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), 2-Butyl-4-chloro-1H-imidazole-5-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H11ClN2O2 |
| Molecular Weight | 202.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Butyl Standards
- Methyl 3-(4-chloro-5-methyl-1H-pyrazol-1-yl)propanoate (CAS 1001500-85-1)
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- 2-(4-chloro-3-methyl-1h-pyraZol-1-yl)propanohydrazide (CAS 1005582-65-9)
- 3-(4-chloro-1h-pyraZol-1-yl)-2-methylpropanohydrazide (CAS 1005585-80-7)
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Recommended Standards
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- 6-Chloro-3-isopropyl-5-methylpyrimidine-2,4(1H,3H)-dione (CAS 1567026-03-2)
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- Pantoprazole Impurity 17 (CAS CATO-C4X-139917)
- 1-(Ethoxymethyl)-1h-indol-6-amine (CAS 1478797-74-8)
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- (Z)-2-(Pyridin-2(1H)-ylidene)acetaldehyde (CAS 922179-77-9)
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