1-(2,2-Difluoroethyl)-3-iodo-1H-pyrazole CAS 1508660-43-2
| CAS No. | 1508660-43-2 |
| Molecular Formula | C5H5F2IN2 |
| Molecular Weight | 258.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 1-(2,2-Difluoroethyl)-3-iodo-1H-pyrazole (CAS 1508660-43-2), a certified reference material (molecular formula C5H5F2IN2, MW 258.01 g/mol) for analytical method development and quality control.
The molecular framework of 1-(2,2-Difluoroethyl)-3-iodo-1H-pyrazole (C5H5F2IN2) is characterized by a nitrile group, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 1-(2,2-Difluoroethyl)-3-iodo-1H-pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5F2IN2 |
| Molecular Weight | 258.01 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Difluoroethyl Standards
- 1-(2,2-Difluoroethyl)-4-iodo-1H-pyrazole (CAS 1344078-17-6)
- 1-(2,2-Difluoroethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 2246778-86-7)
- 1-(2,2-Difluoroethyl)-3-((3,3,3-trifluoropropoxy)methyl)-1H-pyrazole (CAS 1856032-06-8)
- Ethyl 3-(2-(1,1-difluoroethyl)-4-hydroxyphenyl)propanoate (CAS 1800114-99-1)
- 1-(2,2-difluoroethyl)-3,5-dimethyl-1h-pyraZole-4-sulfonyl chloride (CAS 1006487-24-6)
- 2-[(2,2-difluoroethyl)sulfanyl]-5-(trifluoromethyl)aniline (CAS 1183293-41-5)
- 2-(2,2-Difluoroethyl)-3-methyl-6-oxo-2h,6h,7h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1160246-23-0)
- 1-(2,2-difluoroethyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1018142-54-5)
Recommended Standards
- 5-Bromo-4-fluoro-2-(trifluoromethyl)aniline (CAS 1421599-52-1)
- 4-Bromo-3-fluoro-5-(trifluoromethyl)aniline (CAS 1533426-04-8)
- 3-Bromo-4-fluoro-2-(trifluoromethyl)aniline (CAS 1421599-51-0)
- 4-Bromo-2-fluoro-3-(trifluoromethyl)aniline (CAS 159329-03-0)
- (3-Methyl-1H-pyrrol-2-yl)methanol (CAS 151417-50-4)
- 2-{[6-(4-Methylphenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylene}-1H-indene-1,3(2H)-dione (CAS 861213-01-6)
- 3-(4-Fluorophenyl)-3-phenylpropanoic acid (CAS 362-86-7)
- Methyl 4-nitro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-3-carboxylate (CAS 1287669-93-5)
- 4-Methyl-N-[2-(methylamino)ethyl]benzene-1-sulfonamide (CAS 79143-52-5)
- 3-Butyl-5-fluoropyrimidine-2,4(1H,3H)-dione (CAS 90162-96-2)
- Venlafaxine Impurity 78 (CAS CATO-C4X-143478)
- Ethyl 3-{[4-(diethylamino)benzyl]amino}propanoate (CAS 1040688-26-3)
- (2-Phenylthiazol-4-yl)methyl 2-(methylthio)nicotinate (CAS 454686-74-9)
- D-[Phe]6-Semaglutide (CAS CATO-CPTD788633)
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