1-(2-Chlorophenyl)-2-(pyrrolidin-2-yl)ethan-1-one CAS 1515351-75-3
| CAS No. | 1515351-75-3 |
| Molecular Formula | C12H14ClNO |
| Molecular Weight | 223.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(2-Chlorophenyl)-2-(pyrrolidin-2-yl)ethan-1-one (CAS 1515351-75-3) is a high-purity analytical reference standard with the molecular formula C12H14ClNO and a molecular weight of 223.70 g/mol.
The molecular framework of 1-(2-Chlorophenyl)-2-(pyrrolidin-2-yl)ethan-1-one (C12H14ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14ClNO |
| Molecular Weight | 223.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorophenyl Standards
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- 1-[(2-chlorophenyl)methyl]piperidin-4-one (CAS 135576-51-1)
- 1-(3-Chlorophenyl)-2-(pyrrolidin-2-yl)ethan-1-one (CAS 1515307-84-2)
- 2-(4-chlorophenyl)-5-methoxypentanenitrile (CAS 1803594-33-3)
- 2-(4-Chlorophenyl)-1-(pyrrolidin-1-yl)ethan-1-one (CAS 19202-19-8)
- (3-Chlorophenyl)(piperidin-1-yl)methanone (CAS 26163-39-3)
- (3-Chlorophenyl)(piperidin-4-yl)methanone (CAS 887354-02-1)
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Recommended Standards
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- Clonazepam impurity 10 (CAS CATO-C4X-140310)
- 2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(thiazol-2-yl)acetamide (CAS 942947-93-5)
- Des-Leu14-Tirzepatide (CAS CATO-CPTD788959)
- 5-Bromo-1-methyl-3-(pyrimidin-4-ylamino)pyridin-2(1H)-one (CAS 1346672-61-4)
- 1-(6-(Indolin-1-yl)-4-methylpyridin-3-yl)propan-1-one (CAS 1355224-89-3)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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