1-(3-chloro-2-methyl-phenyl)hexahydropyrimidine-2,4-dione CAS 1521251-52-4
| CAS No. | 1521251-52-4 |
| Molecular Formula | C11H11ClN2O2 |
| Molecular Weight | 238.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3-chloro-2-methyl-phenyl)hexahydropyrimidine-2,4-dione.
1-(3-chloro-2-methyl-phenyl)hexahydropyrimidine-2,4-dione (CAS 1521251-52-4), molecular formula C11H11ClN2O2 and molecular weight 238.67 g/mol, is a CATO reference standard with documented purity and traceability.
1-(3-chloro-2-methyl-phenyl)hexahydropyrimidine-2,4-dione (C11H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11ClN2O2 |
| Molecular Weight | 238.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 5-Chloro-3,4,6-trimethyl-1-benzofuran-2-carboxylic acid (CAS 1019111-86-4)
- 3-(7-Chloro-1-methyl-1H-benzoimidazol-2-yl)-propionic acid (CAS 1048922-55-9)
- 1-(2-chloro-6-methyl-phenyl)hexahydropyrimidine-2,4-dione (CAS 1065658-69-6)
- ethyl 4-chloro-6-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (CAS 1082847-63-9)
- 2-Chloro-9-cyclopentyl-7,9-dihydro-8H-purin-8-one (CAS 1124329-93-6)
- 6-Chloro-2-morpholinobenzo[d]oxazole (CAS 1144509-77-2)
- 4-(2-Chloro-5H-pyrrolo[3,2-d]pyrimidin-4-yl)morpholine (CAS 114684-96-7)
- 2-Chloro-6,7-dimethoxyquinolin-4-amine (CAS 1174005-73-2)
Recommended Standards
- 1-(2-chloro-4-methyl-phenyl)hexahydropyrimidine-2,4-dione (CAS 1520561-91-4)
- Ethyl 8-chloro-6-methylimidazo[1,2-a]pyridine-2-carboxylate (CAS 1522191-12-3)
- 6-Chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1443286-90-5)
- Ethyl 6-chloro-8-methylimidazo[1,2-a]pyridine-2-carboxylate (CAS 1523464-12-1)
- 2-(Chloromethyl)benzo[d]oxazole-4-acetonitrile (CAS 1806304-64-2)
- 3-(Methylsulfonamido)benzofuran-2-carboxylic acid (CAS 1263212-81-2)
- (4-Methylthiophen-3-yl)methanamine (CAS 104163-38-4)
- Nilutamide (CAS 63612-50-0)
- 6-Bromo-4-chloro-7-ethyl-1H-indazole (CAS 2569481-54-3)
- Sofosbuvir Impurity 31 (CAS CATO-C4X-105231)
- 6-Amino-4,5-dihydropyridin-2(3H)-one (CAS 99418-74-3)
- 2-Chloro-3-(3-methoxypropoxy)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 2226180-22-7)
- (3-Bromo-5-((tert-butoxycarbonyl)amino)phenyl)boronic acid (CAS 2851879-46-2)
- Semaglutide impurity 290 (CAS CATO-C4X-2226290)
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