7-fluoro-6-iodo-3,4-dihydro-2H-1,4-benzoxazin-3-one CAS 153122-66-8
| CAS No. | 153122-66-8 |
| Molecular Formula | C8H5FINO2 |
| Molecular Weight | 293.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-fluoro-6-iodo-3,4-dihydro-2H-1,4-benzoxazin-3-one.
7-fluoro-6-iodo-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS 153122-66-8) is a high-purity analytical reference standard with the molecular formula C8H5FINO2 and a molecular weight of 293.03 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, 7-fluoro-6-iodo-3,4-dihydro-2H-1,4-benzoxazin-3-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 293.03 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-fluoro-6-iodo-3,4-dihydro-2H-1,4-benzoxazin-3-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5FINO2 |
| Molecular Weight | 293.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 5-Iodo-6-nitro-1,3-dioxaindane (CAS 7106-74-3)
- 3-iodo-5-(trifluoromethyl)-1H-pyridin-2-one (CAS 300851-88-1)
- 5-Iodo-2-nitrobenzoic acid (CAS 35674-28-3)
- 3-Bromo-2-(trifluoromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 1046530-40-8)
- 5-[1-(hydroxyimino)ethyl]-4-methylpyrimidin-2-amine (CAS 1050886-14-0)
- 5-Chloro-3-fluoro-2-methylbenzoic acid (CAS 1365969-71-6)
- 2-(1,3-Thiazol-5-yl)acetonitrile (CAS 50382-34-8)
- 3-(4-nitrophenyl)-1,2-oxazole-5-sulfonyl chloride (CAS 1909337-76-3)
- 7-Bromo-1-methylisoquinoline (CAS 1416713-61-5)
- 2-Amino-4-chloro-6-fluorophenol (CAS 862699-26-1)
- 4-(3-nitro-benzoyl)-1,3-dihydro-imidazol-2-one (CAS 21472-30-0)
- tert-Butyl 3-(2,6-dimethoxyphenyl)-3-hydroxyazetidine-1-carboxylate (CAS 1691616-21-3)
- methyl 5-(piperidin-1-ylmethyl)-1,2-oxazole-3-carboxylate (CAS 932848-38-9)
- 3AEEA-Semaglutide(Endo-AEEA-Semaglutide) (CAS CATO-C4X-2226265)
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