6-Nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine CAS 153436-73-8
| CAS No. | 153436-73-8 |
| Molecular Formula | C15H9F3N4O2 |
| Molecular Weight | 334.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine (CAS 153436-73-8) is a high-purity analytical reference standard with the molecular formula C15H9F3N4O2 and a molecular weight of 334.25 g/mol.
6-Nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine (C15H9F3N4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Nitro-N-(3-(trifluoromethyl)phenyl)quinazolin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H9F3N4O2 |
| Molecular Weight | 334.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Nitro Standards
- 8-(2-Nitro-4-(trifluoromethyl)phenoxy)quinoline (CAS 1020251-87-9)
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Recommended Standards
- 5-(Pyridin-3-yl)-1-[2-(trifluoromethyl)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (CAS 1338653-66-9)
- 2-(3-(2-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)benzoic acid (CAS 1707567-31-4)
- 5-(Pyridin-2-yl)-1-[3-(trifluoromethyl)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (CAS 1326922-71-7)
- 2-(3-(4-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)benzoic acid (CAS 1708400-81-0)
- 2-(4-(Benzyl(ethyl)amino)piperidin-1-yl)acetic acid (CAS 1353951-40-2)
- 4-Chloro-3,3-dimethylbut-1-ene (CAS 65870-89-5)
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