Pregnenolone Impurity 8 CAS 15346-23-3
| CAS No. | 15346-23-3 |
| Molecular Formula | C21H26O2 |
| Molecular Weight | 310.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Pregnenolone Impurity 8 (CAS 15346-23-3) is a certified pharmaceutical impurity reference standard with the molecular formula C21H26O2 and a molecular weight of 310.43 g/mol.
The molecular framework of Pregnenolone Impurity 8 (C21H26O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pregnenolone Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H26O2 |
| Molecular Weight | 310.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Pregnenolone Standards
Recommended Standards
- Dydrogesterone EP Impurity A (CAS 23035-53-2)
- Altrenogest Impurity 1 (CAS CATO-C4X-24831)
- Levonorgestrel EP Impurity M (CAS 51087-61-7)
- Altrenogest impurity 15 (CAS CATO-C4X-248315)
- Cyproheptadine impurity 7 (CAS 4331-45-7)
- Atropine EP Impurity D(6-hydroxyhyoscyamine) (CAS CATO-C4X-148914)
- Dutasteride EP Impurity C (CAS 157307-36-3)
- [S(R)]-N-[(1S)-2-(Diphenylphosphino)-1-phenylethyl]-N,2-dimethyl-2-propanesulfinamide (CAS 1824731-37-4)
- 2-(4-(2-(5-Phenyl-1,3,4-oxadiazol-2-yl)vinyl)styryl)benzonitrile (CAS 63443-08-3)
- (6R)-Tetrahydro-1H-6,8a-(epiminomethano)indolizine-5,9(6H)-dione (CAS 160814-68-6)
- (2-(4-Chlorostyryl)-5-methyloxazol-4-yl)methanol (CAS 89723-99-9)
- 6-Amino-2-methyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one (CAS 337463-77-1)
- 3-[3-(trifluoromethyl)phenyl]-1,2-thiazol-4-amine (CAS 1498589-74-4)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
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