2-Fluoro-2-(1H-pyrazol-1-yl)acetic acid CAS 1536670-72-0
| CAS No. | 1536670-72-0 |
| Molecular Formula | C5H5FN2O2 |
| Molecular Weight | 144.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Fluoro-2-(1H-pyrazol-1-yl)acetic acid (CAS 1536670-72-0), molecular formula C5H5FN2O2 and molecular weight 144.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Fluoro-2-(1H-pyrazol-1-yl)acetic acid (C5H5FN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H5FN2O2 |
| Molecular Weight | 144.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- 2-(4-Fluoro-1H-pyrazol-1-yl)acetic acid (CAS 1174309-02-4)
- 2-Fluoro-2-(furan-3-yl)acetic acid (CAS 1501521-84-1)
- 2-fluoro-2-(furan-2-yl)acetic acid (CAS 1512547-41-9)
- 4-fluoro-5-methylfuran-2-carboxylic acid (CAS 1545471-68-8)
- 4-fluoro-5-methylfuran-3-carboxylic acid (CAS 1554251-92-1)
- 2-fluoro-5-methylfuran-3-carboxylic acid (CAS 1557301-46-8)
- 5-Fluoro-6-hydroxy-2-methylpyrimidin-4(3H)-one (CAS 1598-63-6)
- 5-Fluoro-1-methyl-1H-pyrazole-3-carboxylic acid (CAS 1779937-23-3)
Recommended Standards
- 2-(2-fluorofuran-3-yl)acetic acid (CAS 1526775-35-8)
- 2-(4-fluorofuran-3-yl)acetic acid (CAS 1539739-80-4)
- 2-(5-fluorofuran-2-yl)acetic acid (CAS 1522468-17-2)
- 2-(5-fluorofuran-3-yl)acetic acid (CAS 1510442-94-0)
- 2-(3-(Dimethylamino)phenyl)-3-methylbutan-2-ol (CAS 37487-60-8)
- 6-(Cyclohexyloxy)nicotinaldehyde (CAS 916792-16-0)
- (5-Bromo-2-fluorophenyl)(cyclopropyl)methanamine (CAS 1270377-73-5)
- 2-Chloro-3-isopropylquinoxaline (CAS 75919-93-6)
- Methyl 5,6-difluoronicotinate (CAS 1214336-05-6)
- 3,4-Dichloro-2-fluorobenzoic Acid (CAS 1349715-68-9)
- (S)-1-[(4-Methylphenyl)sulfonyl]-2-phenylaziridine (CAS 149769-84-6)
- 8-Bromo-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-d]thiazole-2-carboxylic acid (CAS 1956382-74-3)
- Orforglipron Impurity 16 (CAS CATO-C4X-323416)
- Tirzepatide Impurity 10 (CAS CATO-C4X-324010)
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