(4-Bromo-3-fluorophenyl)methanesulfonyl Chloride CAS 1536732-85-0
| CAS No. | 1536732-85-0 |
| Molecular Formula | C7H5BrClFO2S |
| Molecular Weight | 287.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(4-Bromo-3-fluorophenyl)methanesulfonyl Chloride (CAS 1536732-85-0) is a high-purity analytical reference standard with the molecular formula C7H5BrClFO2S and a molecular weight of 287.53 g/mol.
The molecular framework of (4-Bromo-3-fluorophenyl)methanesulfonyl Chloride (C7H5BrClFO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5BrClFO2S |
| Molecular Weight | 287.53 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl/Br-containing |
| Sulfur Atoms | 1 |
Related Bromo Standards
- (2-Bromo-4-fluorophenyl)methanesulfonyl chloride (CAS 1178315-16-6)
- (4-Bromo-2-fluorophenyl)methanesulfonyl chloride (CAS 1178830-06-2)
- (3-Bromo-4-fluorophenyl)methanesulfonyl chloride (CAS 1179247-63-2)
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Recommended Standards
- (3-Bromo-5-fluorophenyl)methanesulfonyl chloride (CAS 1513554-71-6)
- 4-chloro-2-iodofuro[2,3-b]pyridine (CAS 1574562-63-2)
- 4-(Bromomethyl)-3-fluorobenzenesulphonyl chloride (CAS 151258-28-5)
- 4-(Bromomethyl)-2-fluorobenzenesulfonyl chloride (CAS 1820684-91-0)
- (2R,4R)-4-Hydroxypiperidine-2-carboxylic acid hydrochloride (CAS 133696-21-6)
- (3-Fluoro-2-(methylthio)phenyl)methanol (CAS 1691658-10-2)
- 2-(3-Oxo-3-phenylpropyl)cyclopentan-1-one (CAS 7095-09-2)
- 8-Methoxy-1,2,4,5-tetrahydro-3H-benzo[c]azepin-3-one (CAS 165530-13-2)
- 1-(2-Ethylcyclohexyl)-1h-1,2,4-triazol-3-amine (CAS 1340535-36-5)
- (S)-3-(((Benzyloxy)carbonyl)amino)-4-phenylbutanoic acid (CAS 26250-86-2)
- n-(2,4,5-Trichlorophenyl)acetamide (CAS 23627-24-9)
- Domperidone Impurity 12 (CAS 107618-26-8)
- 6-Bromopyrimidine-4-carboxamide (CAS 1209458-24-1)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
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