4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic Acid CAS 15448-77-8
| CAS No. | 15448-77-8 |
| Molecular Formula | C10H14O4 |
| Molecular Weight | 198.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic Acid (CAS 15448-77-8), molecular formula C10H14O4 and molecular weight 198.22 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Methoxycarbonyl)bicyclo[2.2.1]heptane-1-carboxylic Acid (C10H14O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14O4 |
| Molecular Weight | 198.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
Related Methoxycarbonyl Standards
- 6-(Methoxycarbonyl)spiro[3.3]heptane-2-carboxylic Acid (CAS 10481-25-1)
- 2-(methoxycarbonyl)spiro[3.3]heptane-2-carboxylic acid (CAS 1888829-23-9)
- 2-(4-(Methoxycarbonyl)bicyclo[2.1.1]Hexan-1-yl)acetic acid (CAS 2109049-42-3)
- 3-(Methoxycarbonyl)bicyclo[2.2.1]heptane-2-carboxylic acid (CAS 76232-01-4)
- 3-Methoxycarbonyl-2,2,5,5-tetramethyl-3-pyrrolidin-1-oxyl (CAS 2154-32-7)
- 2-[4-(methoxycarbonyl)-1h-pyrazol-1-yl]propanoic acid (CAS 1006494-90-1)
- 4-(Methoxycarbonyl)-1H-pyrazole-1-propanoic acid (CAS 1170943-03-9)
- 2-[3-(Methoxycarbonyl)-5-methyl-1H-pyrazol-1-yl]acetic acid (CAS 1211513-40-4)
Recommended Standards
- 2-Butyryl-3,5-dihydroxycyclohex-2-en-1-one (CAS 154037-62-4)
- 5-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine-2-carbonitrile (CAS 1553118-89-0)
- Potassium (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylate (CAS 153831-86-8)
- 2-(1-Amino-3-methylbutyl)oxazole-5-carboxylic acid (CAS 1553988-58-1)
- 2-{4-[(3,4-dichlorophenyl)methoxy]phenyl}-4-(thiophen-2-yl)pyrimidine (CAS 477862-31-0)
- Methyl 2-(1-cyclopropyl-4-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)acetate (CAS 477864-47-4)
- 2-Imino-1-(2-methoxyethyl)-10-methyl-5-oxo-N-(1-phenylethyl)-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 618077-68-2)
- 3-Bromopentan-2-one (CAS 815-48-5)
- 4-Bromobenzo[d]thiazole-2-carboxylic acid (CAS 1187928-21-7)
- 5-(Piperidine-1-sulfonyl)-2,3-dihydro-1h-indole (CAS 874593-99-4)
- Ethyl 3-(5-amino-3-methyl-1H-pyrazol-1-yl)benzoate (CAS 903567-11-3)
- Methyl 2-amino-3-hydroxy-2-methylpropanoate (CAS 309977-52-4)
- 2-(Cyclohexylmethoxy)acetic acid (CAS 711604-10-3)
- Tau Peptide (379-408) trifluoroacetate salt (CAS 1246357-53-8)
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