1-Benzyl-4,4-difluoropiperidine CAS 155137-18-1
| CAS No. | 155137-18-1 |
| Molecular Formula | C12H15F2N |
| Molecular Weight | 211.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-Benzyl-4,4-difluoropiperidine (C12H15F2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
1-Benzyl-4,4-difluoropiperidine (CAS 155137-18-1) is a high-purity analytical reference standard with the molecular formula C12H15F2N and a molecular weight of 211.25 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Benzyl-4,4-difluoropiperidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15F2N |
| Molecular Weight | 211.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Benzyl Standards
- 1-Benzyl-3,3-difluoropiperidine (CAS 741288-41-5)
- 4,4-Difluoropiperidine-1-sulfonyl chloride (CAS 1224929-81-0)
- 3,3-Difluoropiperidine-1-sulfonyl chloride (CAS 1845716-99-5)
- 1-Boc-4,4-difluoropiperidine (CAS 281652-10-6)
- 4,4-Difluoropiperidine-1-sulfonamide (CAS 1015170-98-5)
- Ethyl 3,3-difluoropiperidine-4-carboxylate (CAS 1303973-14-9)
- 1-(4,4-Difluoropiperidine-1-carbonyl)-cyclopropanecarboxylic acid (CAS 1447944-49-1)
- 4,4-Difluoropiperidine-1-carbonyl chloride (CAS 1240057-29-7)
Recommended Standards
- 1-(2,3-Difluorophenyl)cyclopentanemethanamine (CAS 1513064-63-5)
- Guanoxan-d4 (CAS 1794783-67-7)
- 4-[(2,5-difluorophenyl)methyl]piperidine (CAS 150019-62-8)
- N-((1-(trifluoromethyl)cyclopropyl)methyl)thietan-3-amine (CAS 1864833-84-0)
- Okadaic Acid Sodium Salt (CAS 209266-80-8)
- 4-(2,4,5-Trimethylphenyl)piperidine (CAS 946681-99-8)
- (4-(4-Methoxybenzyl)tetrahydro-2H-pyran-4-yl)methanamine hydrochloride (CAS 1380300-43-5)
- Protopine (CAS 130-86-9)
- 3-(tert-Butoxy)-2-(methylamino)phenol (CAS 1243355-88-5)
- n-Ethyl-4-methoxy-2-phenylbutan-1-amine (CAS 1488973-74-5)
- 1-Cyclobutyl-[1,4]diazepane (CAS 851049-21-3)
- (S)-tert-Butyl 2-aminohexanoate (CAS 15911-73-6)
- 5-[1-(3-Chlorophenoxy)ethyl]-4-methyl-4H-1,2,4-triazole-3-thiol (CAS 667414-17-7)
- Neuropeptide Y (18-36) (CAS 114495-97-5)
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