Benzyl 2-(difluoromethyl)piperazine-1-carboxylate CAS 1554029-67-2
| CAS No. | 1554029-67-2 |
| Molecular Formula | C13H16F2N2O2 |
| Molecular Weight | 270.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Benzyl 2-(difluoromethyl)piperazine-1-carboxylate (CAS 1554029-67-2) is a high-purity analytical reference standard with the molecular formula C13H16F2N2O2 and a molecular weight of 270.28 g/mol.
The molecular framework of Benzyl 2-(difluoromethyl)piperazine-1-carboxylate (C13H16F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H16F2N2O2 |
| Molecular Weight | 270.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Benzyl Standards
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Recommended Standards
- 2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide (CAS 15533-09-2)
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- (E)-N-(4-Ethoxyphenyl)-1-(4-nitrophenyl)methanimine (CAS 15485-31-1)
- Benzyl (S)-5-amino-3,3-difluoropiperidine-1-carboxylate (CAS 1562988-38-8)
- [1-(4-methanesulfonylphenyl)ethyl](methyl)amine hydrochloride (CAS 1093630-40-0)
- Ethyl 2-cyanoacetimidate (CAS 42003-88-3)
- 14276-67-6 2,2-Dimethylpropane-1,3-diyl bis(3-oxobutanoate) 6986AA C13H20O6 (CAS 14276-67-6)
- Methyl 2-(3-methoxyphenyl)-2-methylpropanoate (CAS 32454-33-4)
- 1-Ethyl-2-(piperidin-3-ylmethoxy)-1H-benzo[d]imidazole hydrochloride (CAS 1185318-85-7)
- 4-(6-Ethyl-2,6-diazaspiro[3.3]Heptan-2-yl)aniline hydrochloride (CAS 2306275-57-8)
- 5-(4-Methoxyphenyl)-6-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole (CAS 72873-71-3)
- 5,7-Dichloroquinolin-3-amine dihydrochloride (CAS 1296950-84-9)
- Vanadium carbide(IV) (CAS 12070-10-9)
- Peptide 437 (CAS CATO-CPTD788437)
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