3,3,3,3-Tetramethyl-2,2,3,3-tetrahydro-1,1-spirobi[indene]-6,6-diol CAS 1568-80-5
| CAS No. | 1568-80-5 |
| Molecular Formula | C21H24O2 |
| Molecular Weight | 308.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3,3,3,3-Tetramethyl-2,2,3,3-tetrahydro-1,1-spirobi[indene]-6,6-diol.
3,3,3,3-Tetramethyl-2,2,3,3-tetrahydro-1,1-spirobi[indene]-6,6-diol (CAS 1568-80-5) is a high-purity analytical reference standard with the molecular formula C21H24O2 and a molecular weight of 308.41 g/mol.
The molecular framework of 3,3,3,3-Tetramethyl-2,2,3,3-tetrahydro-1,1-spirobi[indene]-6,6-diol (C21H24O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3,3,3,3-Tetramethyl-2,2,3,3-tetrahydro-1,1-spirobi[indene]-6,6-diol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H24O2 |
| Molecular Weight | 308.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Tetramethyl Standards
- (R)-3,3,3',3'-tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol (CAS 2244617-79-4)
- (S)-3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol (CAS 2244617-80-7)
- 2,2,3,3-Tetramethyl-4,7,10,13-tetraoxa-3-silapentadecan-15-ol (CAS 134179-40-1)
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- 2,2,4,4-Tetramethyl-3,8,11,14-tetraoxa-2,4-disilapentadecane (CAS 17065-99-5)
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Recommended Standards
- 2-(2-(4-Octylphenoxy)ethoxy)acetic acid (CAS 154826-10-5)
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- 5-(4-(1-Hydroxypropyl)-2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (CAS 1477561-10-6)
- Methyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-methoxyacetate (CAS 183721-37-1)
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- 2-(methoxymethyl)-4-(piperidin-3-yl)pyrimidine (CAS 914299-49-3)
- 1-(2-Bromopyridin-4-yl)-N,N-dimethylpiperidin-4-amine (CAS 1779133-76-4)
- Methyl 2-(Morpholin-4-yl)propanoate (CAS 110073-17-1)
- Gefitinib Impurity 86 (CAS CATO-C4X-111786)
- 6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene-2-carboxylic acid (CAS 1426082-97-4)
- 4-((4-Chlorophenyl)sulfonyl)butanoyl chloride (CAS 1706453-27-1)
- Cholecystokinin, CCK Tetrapeptide (30-33) (CAS 35144-91-3)
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