(E)-3-(5-fluoro-2-methoxyphenyl)acrylic acid CAS 157518-45-1
| CAS No. | 157518-45-1 |
| Molecular Formula | C10H9FO3 |
| Molecular Weight | 196.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (E)-3-(5-fluoro-2-methoxyphenyl)acrylic acid.
(E)-3-(5-fluoro-2-methoxyphenyl)acrylic acid (CAS 157518-45-1), molecular formula C10H9FO3 and molecular weight 196.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-3-(5-fluoro-2-methoxyphenyl)acrylic acid (C10H9FO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-3-(5-fluoro-2-methoxyphenyl)acrylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9FO3 |
| Molecular Weight | 196.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
Related E Standards
- (E)-3-(4-Fluoro-3-methoxyphenyl)acrylic acid (CAS 1081765-44-7)
- 3-Fluoro-2-methoxycinnamic acid (CAS 1092460-67-7)
- N-(3-Fluoro-2-methylphenyl)-2-(hydroxyimino)acetamide (CAS 114895-95-3)
- N-(4-fluoro-2-methylphenyl)-2-(N-hydroxyimino)acetamide (CAS 1235441-78-7)
- 5-Fluoro-2-methyl-2,3-dihydrobenzofuran-7-carboxylic acid (CAS 123656-38-2)
- 3-(4-Fluoro-2-methylphenyl)-2-oxopropanoic acid (CAS 1249266-47-4)
- Methyl 2-(4-fluoro-3-methylphenyl)-2-oxoacetate (CAS 1267230-81-8)
- 7-Fluoro-6-methoxychroman-4-one (CAS 1273653-44-3)
Recommended Standards
- 6-Fluoro-2,3-dihydrobenzofuran-3-acetic Acid (CAS 1550937-08-0)
- Methyl5-fluoro-2,3-dihydrobenzofuran-7-carboxylate (CAS 1616110-68-9)
- (E)-3-(3-Fluoro-2-methoxyphenyl)acrylic acid (CAS 1548942-24-0)
- Ethyl 3-fluoro-4-formylbenzoate (CAS 1640117-38-9)
- 2-Phenylphenol (CAS 90-43-7)
- o-(Bicyclo[2.2.1]heptan-2-ylmethyl)hydroxylamine (CAS 1560087-43-5)
- Methyl 1-isopropyl-6-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylate (CAS 496793-43-2)
- Momelotinib impurity 14 (CAS 2107522-02-9)
- 2-Amino-4,5-dichlorobenzonitrile (CAS 28568-04-9)
- R-(+)-Warfarin (CAS 5543-58-8)
- 2-Isopropoxy-6-(2-naphthalen-2-yl-ethyl)-benzoic acid methyl ester (CAS 1171921-44-0)
- 3-Fluoro-2-methyl-N-(thiophen-3-ylmethyl)aniline (CAS 1250031-83-4)
- (3,5-Dimethyl-4-propoxyphenyl)methanol (CAS 1039311-97-1)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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