Alectinib impurity 19 CAS 1578259-67-2
| CAS No. | 1578259-67-2 |
| Molecular Formula | C33H46N4O6 |
| Molecular Weight | 594.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Alectinib impurity 19 (CAS 1578259-67-2) is a certified pharmaceutical impurity reference standard with the molecular formula C33H46N4O6 and a molecular weight of 594.74 g/mol.
The molecular framework of Alectinib impurity 19 (C33H46N4O6) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H46N4O6 |
| Molecular Weight | 594.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 4 |
Related Alectinib Standards
- Alectinib Impurity 71 (CAS CATO-C4X-283671)
- Alectinib Impurity 72 (CAS CATO-C4X-283672)
- Alectinib Impurity 87 (CAS CATO-C4X-283687)
- Alectinib Impurity 86 (CAS CATO-C4X-283686)
- Alectinib Impurity 74 (CAS CATO-C4X-283674)
- Alectinib Impurity 78 (CAS CATO-C4X-283678)
- Alectinib Impurity 83 (CAS CATO-C4X-283683)
- Alectinib Impurity 44 (CAS CATO-C4X-283644)
Recommended Standards
- Stercobilin Hydrochloride (CAS 34217-90-8)
- BCN-PEG3-Biotin (CAS 1263166-92-2)
- 3,3'-(9,9-Dimethyl-9H-fluorene-2,7-diyl)difluoranthene (CAS 653599-38-3)
- Biotin-dPEG<SUP>®</SUP><SUB>7</SUB>-NH2 (CAS 1334172-76-7)
- Spironolactone Impurity 15 (CAS CATO-C4X-134515)
- Isavuconazole Impurity 234 (CAS CATO-C4X-1236234)
- Alfacalcidol Impurity 31 (CAS CATO-C4X-139331)
- o-(Cyclohexylmethyl)hydroxylamine (CAS 110238-61-4)
- 3-(3-Fluoro-4-methylphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde (CAS 956202-54-3)
- (2,3-Diamino-6-methylphenyl)methanol (CAS 65658-21-1)
- 3-((Dimethyl(oxo)-lambda6-sulfanylidene)amino)benzaldehyde (CAS 2377300-48-4)
- n-(Furan-2-ylmethyl)-6-hydrazinylpyridine-3-sulfonamide (CAS 926220-15-7)
- Methyl 3-hydroxyhexanoate (CAS 21188-58-9)
- Adrenal Peptide E, bovine (CAS 78355-50-7)
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