(3S,4R,5R)-5-(benzyloxymethyl)-3-fluoro-3-methyl-4-triisopropylsilyloxy-tetrahydrofuran-2-one CAS 1583260-35-8
| CAS No. | 1583260-35-8 |
| Molecular Formula | C22H41FO4Si |
| Molecular Weight | 416.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (3S,4R,5R)-5-(benzyloxymethyl)-3-fluoro-3-methyl-4-triisopropylsilyloxy-tetrahydrofuran-2-one is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(3S,4R,5R)-5-(benzyloxymethyl)-3-fluoro-3-methyl-4-triisopropylsilyloxy-tetrahydrofuran-2-one (CAS 1583260-35-8), molecular formula C22H41FO4Si and molecular weight 416.64 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (3S,4R,5R)-5-(benzyloxymethyl)-3-fluoro-3-methyl-4-triisopropylsilyloxy-tetrahydrofuran-2-one (C22H41FO4Si) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (3S,4R,5R)-5-(benzyloxymethyl)-3-fluoro-3-methyl-4-triisopropylsilyloxy-tetrahydrofuran-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H41FO4Si |
| Molecular Weight | 416.64 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
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