Canagliflozin Impurity 1 CAS 1589590-87-3
| CAS No. | 1589590-87-3 |
| Molecular Formula | C24H25FO5S |
| Molecular Weight | 444.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Canagliflozin Impurity 1 (CAS 1589590-87-3, C24H25FO5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H25FO5S, Canagliflozin Impurity 1 contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 444.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Canagliflozin Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H25FO5S |
| Molecular Weight | 444.52 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Canagliflozin Standards
- Canagliflozin (CAS 842133-18-0)
- Canagliflozin Impurity 103 (CAS CATO-C4X-1123103)
- Canagliflozin Impurity 2 (CAS 2161394-94-9)
- Canagliflozin Impurity 26 (CAS CATO-C4X-112326)
- Canagliflozin Impurity 29 (CAS CATO-C4X-112329)
- Canagliflozin Impurity 78 (CAS 842133-17-9)
- Canagliflozin Impurity 86 (CAS CATO-C4X-112386)
- Canagliflozin Impurity 66 (CAS CATO-C4X-112366)
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