3,6-Dichloro-2-nitroaniline CAS 15944-74-8
| CAS No. | 15944-74-8 |
| Molecular Formula | C6H4Cl2N2O2 |
| Molecular Weight | 207.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3,6-Dichloro-2-nitroaniline.
3,6-Dichloro-2-nitroaniline (CAS 15944-74-8), molecular formula C6H4Cl2N2O2 and molecular weight 207.01 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3,6-Dichloro-2-nitroaniline (C6H4Cl2N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3,6-Dichloro-2-nitroaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4Cl2N2O2 |
| Molecular Weight | 207.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloro Standards
- 3,5-Dichloro-2,6-dihydroxybenzaldehyde (CAS 1204298-54-3)
- 3,5-Dichloro-2-nitroaniline (CAS 122584-83-2)
- 2,3-Dichloro-4,5-dihydroxybenzaldehyde (CAS 125001-04-9)
- 2,6-Dichloro-3-nitroaniline (CAS 13785-48-3)
- 3,4-Dichloro-2-hydroxybenzoic acid (CAS 14010-45-8)
- 2,6-Dichloro-5-methoxypyrimidine-4-carbaldehyde (CAS 1446253-05-9)
- 4,6-Dichloro-2-methoxypyrimidine-5-carbaldehyde (CAS 1446412-96-9)
- 2,5-Dichloro-3,4-dihydroxybenzaldehyde (CAS 152354-09-1)
Recommended Standards
- Methyl 5,6-dichloropyridazine-3-carboxylate (CAS 1591827-51-8)
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- 2,5-Dichloro-3-hydroxybenzoic acid (CAS 165377-89-9)
- 1-(4-Chlorophenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 63695-48-7)
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- N-(2-Fluorobenzyl)-4-isopropoxyaniline (CAS 1037144-79-8)
- 5-Chloro-2-((1-methylpiperidin-4-yl)oxy)aniline (CAS 893751-23-0)
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