1-(5-Chloro-2-fluoro-4-methylphenyl)ethan-1-one CAS 1595747-83-3
| CAS No. | 1595747-83-3 |
| Molecular Formula | C9H8ClFO |
| Molecular Weight | 186.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(5-Chloro-2-fluoro-4-methylphenyl)ethan-1-one (CAS 1595747-83-3) is a high-purity analytical reference standard with the molecular formula C9H8ClFO and a molecular weight of 186.61 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 1-(5-Chloro-2-fluoro-4-methylphenyl)ethan-1-one is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(5-Chloro-2-fluoro-4-methylphenyl)ethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H8ClFO |
| Molecular Weight | 186.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-Chloro-2-cyclopropyl-5-fluoro-6-methylpyrimidine (CAS 1000931-54-3)
- 1-Chloro-3-(3-fluorophenyl)propan-2-one (CAS 1016770-92-5)
- 2-(2-Chloro-4-fluorophenyl)acetimidamide (CAS 1016867-37-0)
- 1-(4-Chloro-3-fluorophenyl)propan-1-one (CAS 1017779-67-7)
- 2-(2-Chloro-4-fluorophenyl)propanal (CAS 1039416-01-7)
- 3-(2-Chloro-4-fluorophenyl)propanal (CAS 1057670-96-8)
- 3-(3-Chloro-2-fluorophenyl)propanal (CAS 1057671-06-3)
- 3-(3-Chloro-4-fluorophenyl)propanal (CAS 1057671-07-4)
Recommended Standards
- Methyl 3-(Chlorosulfonyl)propanoate (CAS 15441-07-3)
- 2’-Chloro-4’-fluoro-3’-methylacetophenone (CAS 173315-53-2)
- 6-Chloro-8-fluorochroman (CAS 1540127-06-7)
- 4-Chloro-2-fluoro-5-methylacetophenone (>90%) (CAS 177211-26-6)
- (3-Bromo-1H-pyrrolo[2,3-b]pyridin-6-yl)methanamine (CAS 1781805-69-3)
- N-{[2-(1H-pyrrol-1-yl)phenyl]methyl}-4-(trifluoromethoxy)benzamide (CAS 866042-34-4)
- 1-(4-(tert-Butyl)phenyl)-1H-1,2,3-triazole-5-carboxamide (CAS 917604-72-9)
- 5-[(2,4-Dichlorophenyl)methyl]-2-phenylpyrimidine-4,6-diamine (CAS 338965-13-2)
- Suvorexant Impurity 34 (CAS CATO-C4X-181234)
- 3-Cyclopropoxy-2-isopropoxy-4-(trifluoromethyl)pyridine (CAS 1243441-93-1)
- Benzyl ((1-((S)-2-aminopropanoyl)pyrrolidin-3-yl)methyl)carbamate (CAS 1354033-30-9)
- 2-Methyl-1,2,3,4-tetrahydroisoquinolin-6-ol (CAS 14097-39-3)
- 3-Amino-N-mesityl-2-methylpropanamide hydrochloride (CAS 1827885-61-9)
- Hepcidin/LEAP-1 (Human); Liver-Expressed Antimicrobial Peptide (CAS 342790-21-0)
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