3-(Difluoromethoxy)cyclobutan-1-amine CAS 1601897-85-1
| CAS No. | 1601897-85-1 |
| Molecular Formula | C5H9F2NO |
| Molecular Weight | 137.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(Difluoromethoxy)cyclobutan-1-amine.
3-(Difluoromethoxy)cyclobutan-1-amine (CAS 1601897-85-1), molecular formula C5H9F2NO and molecular weight 137.13 g/mol, is a CATO reference standard with documented purity and traceability.
3-(Difluoromethoxy)cyclobutan-1-amine (C5H9F2NO) contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H9F2NO |
| Molecular Weight | 137.13 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethoxy Standards
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- (R)-3-(difluoromethoxy)pyrrolidine (CAS 1638784-49-2)
- (S)-3-(difluoromethoxy)pyrrolidine (CAS 1638784-52-7)
- 1-((Difluoromethoxy)methyl)cyclopropan-1-amine (CAS 1780531-13-6)
- 3-((Difluoromethoxy)methyl)azetidine (CAS 1803570-38-8)
- 3-(Difluoromethoxy)cyclobutan-1-ol (CAS 2007917-09-9)
- 2-(difluoromethoxy)-2-methylpropan-1-amine (CAS 1497338-38-1)
- 3-(difluoromethoxy)-1,2-oxazole (CAS 1803562-93-7)
Recommended Standards
- 3-Amino-1-(difluoromethyl)cyclobutan-1-ol (CAS 1423034-51-8)
- (S)-4,4-difluoropiperidin-3-ol (CAS 1620724-08-4)
- 5,5-Difluorooxan-3-amine (CAS 1418199-75-3)
- 2-(3,3-difluoroazetidin-1-yl)ethan-1-ol (CAS 1638364-09-6)
- 2,3-Difluoroiodobenzene (CAS 64248-57-3)
- 3-(3,5-Dimethylbenzyl)piperidin-3-ol (CAS 1340535-69-4)
- 2-Methoxy-3-(methylthio)benzaldehyde (CAS 1378737-56-4)
- 3-Methylhept-4-yn-3-ol (CAS 71065-39-9)
- 2-(4-Methylisoxazol-5-yl)acetic acid (CAS 1368187-80-7)
- Lemborexant impurity 6 (CAS 3070371-41-1)
- 2-(2-(Pyrrolidin-1-yl)phenyl)ethan-1-amine (CAS 1344330-78-4)
- Febuxostat Impurity 5 (CAS 7133-90-6)
- (S)-2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetic acid (CAS 1380792-92-6)
- Anorexigenic Peptide (CAS 69275-10-1)
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