4-chloro-8-fluoroquinolin-3-amine CAS 1602166-76-6
| CAS No. | 1602166-76-6 |
| Molecular Formula | C9H6ClFN2 |
| Molecular Weight | 196.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 196.61 g/mol gives 4-chloro-8-fluoroquinolin-3-amine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-chloro-8-fluoroquinolin-3-amine (CAS 1602166-76-6), molecular formula C9H6ClFN2 and molecular weight 196.61 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-chloro-8-fluoroquinolin-3-amine (C9H6ClFN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6ClFN2 |
| Molecular Weight | 196.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 4-Chloro-6-fluoro-2-methylquinazoline (CAS 1044768-44-6)
- 4-CHloro-1-(4-fluorophenyl)pyrazole (CAS 1152719-73-7)
- 4-Chloro-7-fluoro-2-methylquinazoline (CAS 1206694-32-7)
- 7-Chloro-8-fluoroisoquinolin-3-amine (CAS 1221974-09-9)
- 2-Chloro-5-fluoro-4-methylquinazoline (CAS 1388037-44-2)
- 5-Chloro-6-fluoroquinolin-8-amine (CAS 1394083-91-0)
- 4-Chloro-8-fluoro-2-methylquinazoline (CAS 1404365-01-0)
- 3-Chloro-5-fluoro-2-methylquinoxaline (CAS 1425299-26-8)
Recommended Standards
- (5-Methyl-1,2,4-oxadiazol-3-yl)methanesulfonyl chloride (CAS 1598160-87-2)
- 3-Amino-5-methylisoxazole-4-sulfonyl Chloride (CAS 1701865-36-2)
- 5-(3-Chloro-4-fluorophenyl)-1h-pyrazole (CAS 154258-78-3)
- 2-Chloro-8-fluoroquinolin-4-amine (CAS 1707359-89-4)
- 1-(2-Fluoro-6-(pyrrolidin-1-yl)pyridin-4-yl)-ethanone (CAS 1228665-59-5)
- 1-(Cyclopropylmethyl)-5-methyl-1h-pyrazol-4-amine (CAS 1393100-72-5)
- 1-Bromo-5-chloro-2-[chloro(difluoro)-methoxy]-3-fluoro-benzene (CAS 1417568-70-7)
- 2-Methyl-6-oxo-1,6-dihydropyridine-3,4-dicarbonitrile (CAS 400081-34-7)
- 1-(3-Butoxyphenyl)ethanamine (CAS 925180-09-2)
- 3-Methyl-2-(trifluoromethyl)-1H-indole (CAS 913955-35-8)
- ((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol (CAS 130277-32-6)
- 7-Nitrothieno[3,2-b]pyridine 4-oxide (CAS 104273-28-1)
- 4-tert-Butyl-3-methylbenzophenone (CAS 55709-37-0)
- ([D?]Val?·1?)-C-Peptide (human) (CAS 1802078-41-6)
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