2-(Ethylthio)-2,2-diphenylacetic acid CAS 16036-85-4
| CAS No. | 16036-85-4 |
| Molecular Formula | C16H16O2S |
| Molecular Weight | 272.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Ethylthio)-2,2-diphenylacetic acid (CAS 16036-85-4) is a high-purity analytical reference standard with the molecular formula C16H16O2S and a molecular weight of 272.36 g/mol.
The molecular framework of 2-(Ethylthio)-2,2-diphenylacetic acid (C16H16O2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H16O2S |
| Molecular Weight | 272.36 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Sulfur Atoms | 1 |
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- N-(5-(Ethylthio)-1,3,4-thiadiazol-2-yl)-1-methyl-1H-1,2,3-triazole-4-carboxamide (CAS 1207009-69-5)
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Recommended Standards
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- 4-(tert-Pentyl)phenyl 4-piperidinyl etherhydrochloride (CAS 1219963-86-6)
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- (3-Chloro-4-isobutoxyphenyl)methanol (CAS 1248965-79-8)
- 4,4,5,5-Tetramethyl-2-(3-(2,2,2-trifluoroethyl)bicyclo[1.1.1]pentan-1-yl)-1,3,2-dioxaborolane (CAS 2826264-05-3)
- tert-Butyl (1-(hydroxymethyl)cyclohexyl)carbamate (CAS 187610-67-9)
- Mizolastine Impurity N1 (CAS 108612-60-8)
- N-(2-(Thiophen-3-yl)benzyl)cyclopropanecarboxamide (CAS 1795193-13-3)
- 4-[3-(Benzyloxy)phenyl]-3h,4h,5h,6h,7h-imidazo[4,5-c]pyridine-6-carboxylic acid (CAS 1426142-73-5)
- Semaglutide Impurity 139 (CAS CATO-C4X-2226139)
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