2-(1H-Imidazol-1-yl)acetyl chloride CAS 160975-66-6
| CAS No. | 160975-66-6 |
| Molecular Formula | C5H5ClN2O |
| Molecular Weight | 144.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(1H-Imidazol-1-yl)acetyl chloride (C5H5ClN2O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 2-(1H-Imidazol-1-yl)acetyl chloride (CAS 160975-66-6), a certified reference material (molecular formula C5H5ClN2O, MW 144.56 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(1H-Imidazol-1-yl)acetyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5ClN2O |
| Molecular Weight | 144.56 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related H Standards
- 2-((1H-Imidazol-2-yl)thio)ethan-1-ol (CAS 1314953-79-1)
- 2-(1H-imidazol-2-yl)propanoic acid (CAS 1492007-00-7)
- 3-imidazol-1-yl-propionic acid (CAS 18999-45-6)
- 2-(1H-imidazol-1-yl)propanoic acid (CAS 753489-91-7)
- (1H-Imidazol-2-yl)dimethylphosphine oxide (CAS 1009112-25-7)
- 2-(1H-Imidazol-1-yl)pyridine (CAS 25700-14-5)
- 3-(1H-Imidazol-1-yl)pyridine (CAS 25700-15-6)
- 3-(1H-Imidazol-5-yl)pyridine (CAS 51746-85-1)
Recommended Standards
- 4-Chloropyridazine-3,5-diamine (CAS 1500-83-0)
- 5-(Chloromethyl)furan-2-carbaldehyde (CAS 1623-88-7)
- 4-Chloropyrimidine-2,5-diamine (CAS 14631-09-5)
- 3-chloro-4-methoxy-pyridazine (CAS 1677-81-2)
- 3-(6-Methyl-1,1-dioxido-4h-1,2,4-benzothiadiazin-3-yl)propanoic acid (CAS 101063-96-1)
- 2-[1-(difluoromethyl)-1h-pyrazol-3-yl]acetic acid (CAS 1354706-21-0)
- 1-Chloro-3-(difluoromethyl)-5-fluorobenzene (CAS 1214333-10-4)
- 2-(Tetrahydropyrimidin-2(1H)-ylidene)cyclooctanone (CAS 108816-11-1)
- 3-(1-Ethyl-5-methyl-1h-pyrazol-4-yl)-1-phenyl-1h-pyrazole-4-carboxylic acid (CAS 1006348-70-4)
- 2-Methoxy-4-nitrobenzenesulfonyl fluoride (CAS 21320-94-5)
- N4-(4-Fluorophenyl)-7-methoxyquinazoline-4,6-diamine (Dacomitinib Impurity) (CAS 1562180-31-7)
- rel-(1R,2S,4r)-1,2-difluoro-4-(iodomethyl)cyclopentane (CAS 1036721-60-4)
- Methyl 4-Morpholinobenzoate (CAS 23676-05-3)
- Semaglutide impurity 85 (CAS CATO-C4X-222685)
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