TH287, 97%, a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM CAS 1609960-30-6

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including TH287, 97%, a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM.

TH287, 97%, a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM (CAS 1609960-30-6) is a high-purity analytical reference standard with the molecular formula C11H10Cl2N4 and a molecular weight of 269.13 g/mol.

Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, TH287, 97%, a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 269.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), TH287, 97%, a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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