(1R,4r)-4-(fluoromethyl)cyclohexan-1-amine CAS 1621677-57-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1R,4r)-4-(fluoromethyl)cyclohexan-1-amine.

(1R,4r)-4-(fluoromethyl)cyclohexan-1-amine (CAS 1621677-57-3), molecular formula C7H14FN and molecular weight 131.19 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (1R,4r)-4-(fluoromethyl)cyclohexan-1-amine (C7H14FN) is characterized by fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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