Capecitabine Impurity 45 CAS 162204-22-0
| CAS No. | 162204-22-0 |
| Molecular Formula | C19H26FN3O8 |
| Molecular Weight | 443.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Capecitabine Impurity 45.
As a process- or degradation-related impurity, Capecitabine Impurity 45 (CAS 162204-22-0, C19H26FN3O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Capecitabine Impurity 45 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 443.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Capecitabine Impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H26FN3O8 |
| Molecular Weight | 443.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Capecitabine Standards
- Capecitabine Impurity 13 (CAS CATO-C4X-102413)
- Capecitabine Impurity 46 (CAS 1341231-51-3)
- Capecitabine EP Impurity G (CAS 162204-20-8)
- Capecitabine Impurity 39 (CAS CATO-C4X-102439)
- Capecitabine Impurity 22 (CAS CATO-C4X-102422)
- Capecitabine Impurity 17 (CAS 1262133-68-5)
- Capecitabine Impurity 24 (CAS CATO-C4X-102424)
- Capecitabine Impurity 8 (CAS 1262133-66-3)
Recommended Standards
- 2,3-Dimethoxy-11-(4-(trifluoromethyl)phenyl)-5,11,12,12a-tetrahydropyrazolo[3',4':4,5]pyrido[2,1-a]isoquinolin-8(6H)-one (CAS 685108-22-9)
- 2,3-Dimethoxy-11-(3-(trifluoromethyl)phenyl)-5,11,12,12a-tetrahydropyrazolo[3',4':4,5]pyrido[2,1-a]isoquinolin-8(6H)-one (CAS 685107-27-1)
- Linezolid Impurity 73 (CAS CATO-C4X-107373)
- 1-(2-(Dimethylamino)ethyl)-4-(3-fluoro-4-methoxybenzoyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one (CAS 618074-79-6)
- Fudosteine Impurity 58 HCl (CAS CATO-C4X-144758)
- Vortioxetine Impurity 93 (CAS CATO-C4X-105693)
- Ganirelix(4-10)Impurity (CAS CATO-C4X-23732)
- 3-Morpholinopropanoic acid hydrobromide (CAS 28025-77-6)
- 4-(2-(4-Methoxyphenyl)hydrazineylidene)-4H-pyrazole-3,5-diamine (CAS 99285-51-5)
- N-(Pyridin-4-yl)-6-(4-(thiophen-2-ylsulfonyl)piperazin-1-yl)pyridazin-3-amine (CAS 1021262-37-2)
- (2R,3R,4R)-2-((S)-1-(((Benzyloxy)carbonyl)amino)ethyl)-5-(2,2,2-trichloro-1-iminoethoxy)tetrahydrofuran-3,4-diyl dibenzoate (CAS 2244622-30-6)
- 556050-49-8 N-[4-(1H,1H,2H,2H-Perfluorodecyl)benzyloxycarbonyloxy]succinimide N-[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecyl) benzyloxycarbonyloxy]succinimide (CAS 556050-49-8)
- Baclofen Impurity 10 (CAS 1346603-21-1)
- Galanin-Like Peptide (rat) trifluoroacetate salt (CAS 245114-97-0)
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