1-(Tert-butoxy)-4-(trifluoromethyl)benzene CAS 16222-44-9
| CAS No. | 16222-44-9 |
| Molecular Formula | C11H13F3O |
| Molecular Weight | 218.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(Tert-butoxy)-4-(trifluoromethyl)benzene (C11H13F3O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 1-(Tert-butoxy)-4-(trifluoromethyl)benzene (CAS 16222-44-9), a certified reference material (molecular formula C11H13F3O, MW 218.22 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(Tert-butoxy)-4-(trifluoromethyl)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H13F3O |
| Molecular Weight | 218.22 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
Related Tert Standards
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- 4-Butoxy Coumarin (CAS 71386-90-8)
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- 4-Butoxy-3,5-difluorobenzenethiol (CAS 1379362-65-8)
- 6-(tert-Butoxy)-3,4-dihydronaphthalen-1(2H)-one (CAS 1273651-64-1)
- 6-Butoxy-3,4-dihydro-2H-naphthalen-1-one (CAS 28945-95-1)
- 3-Butoxy-5-chloro-4-fluorophenol (CAS 1881290-39-6)
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Recommended Standards
- 3-(5-(4-Fluorophenyl)furan-2-yl)prop-2-en-1-ol (CAS 1563771-62-9)
- 1-N-propyl-4-(trifluoromethyl)benzene-1,2-diamine (CAS 164221-21-0)
- 3-[(4-Fluorophenyl)(hydroxy)methyl]phenol (CAS 1514332-73-0)
- 7,7-Difluoro-2-(methylthio)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one (CAS 1644414-74-3)
- (Fluoromethyl)(phenyl)(2,3,4,5-tetramethylphenyl)sulfonium tetrafluoroborate (CAS 1009088-40-7)
- Methyl 2-(4-fluoro-2-methylphenyl)-2-hydroxyacetate (CAS 1251222-83-9)
- NDI812-2ThBr (CAS 1178586-27-0)
- 7-Fluoro-3-iodo-6-methoxyquinoline (CAS 1823963-66-1)
- (4-Bromo-5-chlorofuran-2-yl)methanol (CAS 1779131-13-3)
- 2-benzyl-5H,6H,7H,8H-imidazo[1,2-a]pyrazine dihydrochloride (CAS 1803605-93-7)
- 3-(Difluoromethyl)-5-iodo-4-methoxypyridin-2-amine (CAS 1804676-71-8)
- 2,6-Diamino-4-(2-butoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile (CAS 337496-64-7)
- N-Benzyl-2-hydroxyquinoline-4-carboxamide (CAS 528831-13-2)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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