2-(3-Chlorophenoxy)thiazole-4-carboxylic acid CAS 162276-99-5
| CAS No. | 162276-99-5 |
| Molecular Formula | C10H6ClNO3S |
| Molecular Weight | 255.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(3-Chlorophenoxy)thiazole-4-carboxylic acid (CAS 162276-99-5), molecular formula C10H6ClNO3S and molecular weight 255.68 g/mol, is a CATO reference standard with documented purity and traceability.
2-(3-Chlorophenoxy)thiazole-4-carboxylic acid (C10H6ClNO3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(3-Chlorophenoxy)thiazole-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6ClNO3S |
| Molecular Weight | 255.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chlorophenoxy Standards
- 2-(3-Chlorophenoxy)-1-morpholinoethan-1-one (CAS 301309-50-2)
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- 5-(1-(2-Chlorophenoxy)ethyl)-1,3,4-thiadiazol-2-amine (CAS 78385-17-8)
- 5-(1-(4-Chlorophenoxy)ethyl)-1,3,4-thiadiazol-2-amine (CAS 78784-06-2)
- 5-(2-(4-Chlorophenoxy)ethyl)-1,3,4-thiadiazol-2-amine (CAS 842973-73-3)
- 424798-45-8 5-[(4-chlorophenoxy)methyl]-4-methyl-4H-1,2,4-triazole-3-thiol DTXSID70360668 (CAS 424798-45-8)
- 1-(2-(2-Chlorophenoxy)ethyl)piperidin-3-ol (CAS 1208857-73-1)
Recommended Standards
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- 5-Chloro-3-[(4-nitrophenyl)methyl]-1,2,4-thiadiazole (CAS 1221342-62-6)
- N'-[(1E)-(2-Chloro-1,3-thiazol-5-yl)methylidene]furan-2-carbohydrazide (CAS 478067-98-0)
- N-(4-Methoxyphenyl)-3-(3-methylphenyl)-2-(2H-1,2,3,4-tetrazol-5-yl)propanamide (CAS 483993-95-9)
- 6-({[(4-chlorophenyl)methyl]sulfanyl}methyl)-2-phenylpyrimidin-4-ol (CAS 339279-11-7)
- 1-(2-Chloroethyl)-2-imidazolidinone, 97% (CAS 2387-20-4)
- 2-(4-Acetamidophenoxy)-N-(1-cyanocyclohexyl)acetamide (CAS 851897-89-7)
- (4S,5R)-4-Isobutyl-5-phenyloxazolidin-2-one (CAS 104454-73-1)
- 2-(4-Fluorophenyl)-1-phenyl-1H-pyrrole (CAS 315179-68-1)
- 6,7-Dihydro-4H-pyrano[3,4-d]isoxazol-3-amine (CAS 1368125-56-7)
- 2-Bromo-9-(2-naphthyl)-9H-carbazole (CAS 1427316-53-7)
- 3-(4-Bromophenyl)propanamide (CAS 57775-11-8)
- Peptide 432 (CAS CATO-CPTD788432)
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