Ethyl 6-chloro-5-cyano-2-propylnicotinate CAS 1622982-74-4
| CAS No. | 1622982-74-4 |
| Molecular Formula | C12H13ClN2O2 |
| Molecular Weight | 252.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 6-chloro-5-cyano-2-propylnicotinate.
Ethyl 6-chloro-5-cyano-2-propylnicotinate (CAS 1622982-74-4) is a high-purity analytical reference standard with the molecular formula C12H13ClN2O2 and a molecular weight of 252.70 g/mol.
Ethyl 6-chloro-5-cyano-2-propylnicotinate (C12H13ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13ClN2O2 |
| Molecular Weight | 252.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- 7'-Chloro-1',2,3,4',5,6-hexahydro-3'H-spiro[pyran-4,2'-quinoxalin]-3'-one (CAS 1546465-77-3)
- 6-Chloro-4-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1628055-64-0)
- 2-Bromo[1]benzothieno[3,2-b][1]benzothiophene (CAS 1398397-58-4)
- (2-Fluoro-4-(pyrrolidin-1-yl)phenyl)boronic acid (CAS 1876473-45-8)
- 2-Chloro-N-(4-ethoxyphenyl)acetamide (CAS 2153-08-4)
- 7-Bromo-4-fluoro-1H-benzimidazole (CAS 1360968-91-7)
- 4-iodo-1-methyl-1H-imidazole-5-carbaldehyde (CAS 189014-13-9)
- Cefcapene Impurity 42 (CAS CATO-C4X-182442)
- Potassium Propionate (CAS 327-62-8)
- 4-Cyano-3-(difluoromethyl)-5-hydroxypyridine-2-acetonitrile (CAS 1807024-11-8)
- 3-ethyl-4-hydroxybenzonitrile (CAS 4997-55-1)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
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