2-(4-(Difluoromethoxy)-3-((methoxymethoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1623766-69-7
| CAS No. | 1623766-69-7 |
| Molecular Formula | C16H23BF2O5 |
| Molecular Weight | 344.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(4-(Difluoromethoxy)-3-((methoxymethoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1623766-69-7) is a high-purity analytical reference standard with the molecular formula C16H23BF2O5 and a molecular weight of 344.16 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2-(4-(Difluoromethoxy)-3-((methoxymethoxy)methyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 344.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C16H23BF2O5 |
| Molecular Weight | 344.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
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Recommended Standards
- 9-Bromo-8-fluoro-4,5-dihydrobenzo[2,3]oxepino[4,5-d]thiazole-2-carboxylic acid (CAS 1451085-04-3)
- (3Z)-3-{[(4-bromophenyl)amino]methylidene}-3,4-dihydro-2H-1-benzopyran-2,4-dione (CAS 1638273-90-1)
- Gemcitabine Impurity 18 (CAS 139729-89-8)
- ((2R,3R,4R,5R)-4-Fluoro-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate (CAS 64461-75-2)
- 2-(4-Benzylphenoxy)-5-chloroaniline (CAS 946715-22-6)
- 3,5-Dibromo-L-phenylalanine (CAS 634917-08-1)
- 3,4-Dihydrophenanthren-1(2H)-one (CAS 573-22-8)
- 5-Ethylthiophene-3-sulfonyl chloride (CAS 1245823-95-3)
- 1,1,1,3,5,5,5-Heptamethyl-3-phenyltrisiloxane (CAS 546-44-1)
- 3-([1,1'-Biphenyl]-4-yl)acrylaldehyde (CAS 39703-89-4)
- Acetophenone-d8 (CAS 19547-00-3)
- Tert-butyl (S)-6-methyl-2,7-diazaspiro[3.5]Nonane-2-carboxylate (CAS 1263281-19-1)
- 4-(1,4-oxazepane-4-carbonyl)aniline hydrochloride (CAS 1803589-66-3)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
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