5-Amino-2-(3-chloro-4-fluorobenzoyl)isoxazol-3(2H)-one CAS 1630763-98-2
| CAS No. | 1630763-98-2 |
| Molecular Formula | C10H6ClFN2O3 |
| Molecular Weight | 256.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Amino-2-(3-chloro-4-fluorobenzoyl)isoxazol-3(2H)-one.
CATO supplies 5-Amino-2-(3-chloro-4-fluorobenzoyl)isoxazol-3(2H)-one (CAS 1630763-98-2), a certified reference material (molecular formula C10H6ClFN2O3, MW 256.62 g/mol) for analytical method development and quality control.
5-Amino-2-(3-chloro-4-fluorobenzoyl)isoxazol-3(2H)-one (C10H6ClFN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6ClFN2O3 |
| Molecular Weight | 256.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
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Recommended Standards
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- 5-(Chlorosulfonyl)-2,4-difluorobenzoic acid (CAS 53916-70-4)
- 1-(2-chloro-4-fluorobenzyl)-3-nitro-1H-1,2,4-triazole (CAS 676249-42-6)
- 5-Phenyl-2,3’-bipyridine (CAS 340026-73-5)
- 1-Methyl-4-nitro-1H-pyrrol-3-amine (CAS 72083-66-0)
- 4-(Benzyloxy)-2-isopropylbenzoic acid (CAS 851334-71-9)
- 1-Methyl-4-indolecarboxylic Acid (CAS 90924-06-4)
- O-tert-Butyl-dimethylsilyl Curcumin (CAS 911292-36-9)
- 1-Methylpiperazine-2-carboxylic acid (CAS 1246609-06-2)
- N-(6-methylpyridin-2-yl)pivalamide (CAS 86847-79-2)
- 4-chlorophenylhydroxylamine (CAS 823-86-9)
- 3-(2-Methyl-1H-benzo[d]imidazol-6-yl)propanoic acid (CAS 842972-77-4)
- Peptide Impurity 82 (CAS 10491-78-8)
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