Ethyl 2-amino-4-(difluoromethyl)thiazole-5-carboxylate CAS 1631960-98-9

Purity 97%+In StockPharmaceutical Standards
CAS No.1631960-98-9
Molecular FormulaC7H8F2N2O2S
Molecular Weight222.21 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

Ethyl 2-amino-4-(difluoromethyl)thiazole-5-carboxylate CAS 1631960-98-9 chemical structure

Description

The occurrence of Ethyl 2-amino-4-(difluoromethyl)thiazole-5-carboxylate is closely related to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies Ethyl 2-amino-4-(difluoromethyl)thiazole-5-carboxylate (CAS 1631960-98-9), a certified reference material (molecular formula C7H8F2N2O2S, MW 222.21 g/mol) for analytical method development and quality control.

The molecular framework of Ethyl 2-amino-4-(difluoromethyl)thiazole-5-carboxylate (C7H8F2N2O2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC7H8F2N2O2S
Molecular Weight222.21 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1993
Halogen ContentF-containing
Nitrogen Atoms2
Sulfur Atoms1

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